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Titolo:
Pharmacological identification of acetylcholine receptor subtypes in echinoderm smooth muscle (Sclerodactyla briareus)
Autore:
Devlin, CL; Schlosser, W; Belz, DT; Kodiak, K; Nash, RF; Zitomer, N;
Indirizzi:
Penn State Univ, Abington Coll, Dept Biol, Abington, PA 19001 USA Penn State Univ Abington PA USA 19001 , Dept Biol, Abington, PA 19001 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY
fascicolo: 1, volume: 125, anno: 2000,
pagine: 53 - 64
SICI:
1367-8280(200001)125:1<53:PIOARS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-7 SUBUNITS; SYNAPTIC TRANSMISSION; MUSCARINIC RECEPTOR; ASCARIS-SUUM; CALCIUM; PHYSOSTIGMINE; EPIBATIDINE; NEURONS; AGONIST; CHANNEL;
Keywords:
acetylcholine receptors; atropine; D-tubocurarine; epibatidine; methyllycaconitine; muscarine; nicotine; oxotremorine; pilocarpine; pirenzepine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Devlin, CL Penn State Univ, Abington Coll, Dept Biol, Abington, PA 19001 USA Penn State Univ Abington PA USA 19001 , Abington, PA 19001 USA
Citazione:
C.L. Devlin et al., "Pharmacological identification of acetylcholine receptor subtypes in echinoderm smooth muscle (Sclerodactyla briareus)", COMP BIOC C, 125(1), 2000, pp. 53-64

Abstract

Contractions of an echinoderm (sp. Sclerodactyla briarieus) smooth muscle,the longitudinal muscle of the body wall (LMBW), were evoked by acetylcholine (ACh) and agonists: epibatidine, muscarine and nicotine (in order of force generation: ACh > muscarine = epibatidine > nicotine). ACh-induced contractions were blocked by atropine by 50%, and methoctramine, by 30%. ACh responses were also blocked by 25% by methyllycaconitine (MLA) but not by D-tubocurarine (dTC). Muscarine initiated large contractions that were completely blocked by atropine. To elucidate possible muscarinic ACh receptor (mAChR) subtypes. muscarinic agonists (oxotremorine, pilocarpine) and antagonists (methoctramine, pirenzepine) were tested. Oxotremorine, pilocarpine, andpirenzepine each enhanced resting tonus and potentiated ACh-induced contractions (order of potency: pilocarpine > oxotremorine = pirenzepine). Muscarine, oxotremorine or pirenzepine generated phasic, rhythmic contractions. Nicotine-induced contractions were almost completely blocked by dTC but werenot altered by atropine. Large contractions evoked by epibatidine were potentiated by dTC whereas atropine had no effect on them. MLA blocked spontaneous rhythmicity. Cholinesterase inhibitors, neostigmine or physostigmine, caused marked potentiation of ACh-induced contractions and initiated rhythmic slow wave contractions in previously quiescent muscles. The present pharmacological evidence points to the co-existence of excitatory nicotinic AChreceptor (nAChRs) and mAChRs where nAChRs possibly modulate tone, and the mAChRs initiate and enhance rhythmicity. (C) 2000 Elsevier Science Inc. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 20:13:05