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Titolo:
Organic synthesis using chemical tags: The "third leg" of parallel synthesis
Autore:
Porco, JA;
Indirizzi:
Boston Univ, Metcalf Ctr Sci & Engn, Dept Chem, Boston, MA 02215 USA Boston Univ Boston MA USA 02215 i & Engn, Dept Chem, Boston, MA 02215 USA Boston Univ, Metcalf Ctr Sci & Engn, Ctr Streamlined Synth, Boston, MA 02215 USA Boston Univ Boston MA USA 02215 r Streamlined Synth, Boston, MA 02215 USA
Titolo Testata:
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
fascicolo: 2, volume: 3, anno: 2000,
pagine: 93 - 102
SICI:
1386-2073(200004)3:2<93:OSUCTT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASE COMBINATORIAL SYNTHESIS; FLUOROUS TIN REACTANTS; STILLE COUPLINGS; PROTECTING GROUP; PURIFICATION; REAGENTS; LIBRARY; EXTRACTION; ETHER; DISACCHARIDE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Porco, JA Boston Univ, Metcalf Ctr Sci & Engn, Dept Chem, 590 CommonwealthAve, Boston, MA 02215 USA Boston Univ 590 Commonwealth Ave Boston MA USA 02215 A 02215 USA
Citazione:
J.A. Porco, "Organic synthesis using chemical tags: The "third leg" of parallel synthesis", COMB CHEM H, 3(2), 2000, pp. 93-102

Abstract

Increasing emphasis has recently been placed on the development of synthetic methods which effectively couple chemical synthesis and purification. For example, new formats for parallel synthesis are being developed which involve attachment of chemical tags to both reagents, reactants, and substrates to permit their chemoselective removal from reaction mixtures. The driving force for the development of tagged organic reagents is the ability to use standard solution-phase chemistry methods and reaction monitoring techniques (e.g. TLC and HPLC). In this mini-review, we will outline recent developments on the growing class of chemically tagged reagents, reactants, and substrates and highlight examples of their use in multistep synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:25:10