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Titolo:
Basic fibroblast growth factor increases tissue factor expression in circulating monocytes and in vascular wall
Autore:
Corseaux, D; Meurice, T; Six, I; Rugeri, L; Ezekowitz, MD; Rouvier, P; Bordet, R; Bauters, C; Jude, B;
Indirizzi:
Ctr Hosp Reg Univ, Hematol Lab, Lille, France Ctr Hosp Reg Univ Lille France osp Reg Univ, Hematol Lab, Lille, France Ctr Hosp Reg Univ, Serv Cardiol & Hemodynam, Lille, France Ctr Hosp Reg Univ Lille France Serv Cardiol & Hemodynam, Lille, France Ctr Hosp Reg Univ, Serv Pharmacol, Lille, France Ctr Hosp Reg Univ LilleFrance Reg Univ, Serv Pharmacol, Lille, France Ctr Hosp Reg Univ, Serv Commun Imagerie Intervent, Lille, France Ctr Hosp Reg Univ Lille France Commun Imagerie Intervent, Lille, France Ctr Hosp Reg Univ, Lab Anat & Cytol Pathol, Lille, France Ctr Hosp Reg Univ Lille France , Lab Anat & Cytol Pathol, Lille, France Fac Med Lille, F-59045 Lille, France Fac Med Lille Lille France F-59045Fac Med Lille, F-59045 Lille, France Yale Univ, Sect Cardiovasc Med, New Haven, CT USA Yale Univ New Haven CT USA Univ, Sect Cardiovasc Med, New Haven, CT USA
Titolo Testata:
CIRCULATION
fascicolo: 16, volume: 101, anno: 2000,
pagine: 2000 - 2006
SICI:
0009-7322(20000425)101:16<2000:BFGFIT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
KINASE-C ACTIVATION; SMOOTH-MUSCLE CELLS; DIETARY L-ARGININE; PROCOAGULANT ACTIVITY; PROTEIN-KINASE; HYPERCHOLESTEROLEMIC RABBIT; BALLOON INJURY; UP-REGULATION; GENE; ENDOTHELIUM;
Keywords:
growth substances; leukocytes; vessels;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Jude, B Hop Cardiol, Hematol Lab, Blvd Prof J Leclercq, F-59037 Lille, France Hop Cardiol Blvd Prof J Leclercq Lille France F-59037 lle, France
Citazione:
D. Corseaux et al., "Basic fibroblast growth factor increases tissue factor expression in circulating monocytes and in vascular wall", CIRCULATION, 101(16), 2000, pp. 2000-2006

Abstract

Background-Basic fibroblast growth factor (bFGF) promotes vascular repair and angiogenesis and can induce in vitro tissue factor (TF), a potent agentinitiating thrombogenesis, which probably plays a role in angiogenesis. Weinvestigated whether bFGF administration induced TF expression by monocytes and vascular cells. Methods and Results-We studied TF expression in normally fed (n=16) and cholesterol-fed (2% for 6 weeks, n=16) rabbits. Animals were then randomized to receive intravenous bFGF (2.5 mu g twice weekly for 3 weeks) or saline injections. TF expression was evaluated in mononuclear cells from arterial blood and in aortic sections by an immunohistochemical assay using a monoclonal anti-rabbit TF antibody (activator protein 1). Monocyte TF expression was increased by bFGF administration in both normal and hypercholesterolemicrabbits (129+/-45 versus 19+/-3 mU TF/1000 monocytes, P<0.05, and 31+/-12 versus 7+/-1 mU TF/1000 monocytes, P<0.005, respectively) and was further increased by stimulation of monocytes by endotoxin in vitro. TF expression was lower in hypercholesterolemic rabbits than in normal rabbits. In the media of the vascular wall, bFGF induced strong TF expression in normal rabbits and only weak TF expression in hypercholesterolemic ones. Conclusions-This study demonstrates that systemic administration of bFGF induces an impressive increase of TF expression in circulating monocytes andin the vascular wall in normal and to a lower extent in hypercholesterolemic rabbits. The significance of this observation in terms of inducing thrombosis in vivo needs clarification.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:42:29