Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Differential effects of discrete subarea-specific lesions of the rat medial prefrontal cortex on amphetamine- and cocaine-induced behavioural sensitization
Autore:
Tzschentke, TM; Schmidt, WJ;
Indirizzi:
Univ Tubingen, Inst Zool, Dept Neuropharmacol, D-72074 Tubingen, Germany Univ Tubingen Tubingen Germany D-72074 rmacol, D-72074 Tubingen, Germany
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 5, volume: 10, anno: 2000,
pagine: 488 - 498
SICI:
1047-3211(200005)10:5<488:DEODSL>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; IBOTENIC ACID LESIONS; MESOCORTICAL DOPAMINE NEURONS; CONDITIONED PLACE PREFERENCE; STRESS-INDUCED SENSITIZATION; EXCITATORY AMINO-ACIDS; NUCLEUS-ACCUMBENS; FRONTAL-CORTEX; EXTRACELLULAR DOPAMINE; ANTERIOR CINGULATE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
107
Recensione:
Indirizzi per estratti:
Indirizzo: Tzschentke, TM Grunenthal GmbH, Res & Dev, Dept Pharmacol, Postfach 500444, D-52088 Aachen, Germany Grunenthal GmbH Postfach 500444 Aachen Germany D-52088 any
Citazione:
T.M. Tzschentke e W.J. Schmidt, "Differential effects of discrete subarea-specific lesions of the rat medial prefrontal cortex on amphetamine- and cocaine-induced behavioural sensitization", CEREB CORT, 10(5), 2000, pp. 488-498

Abstract

The medial prefrontal cortex (mPFC) of the rat is thought to be important for the initiation of behavioural sensitization. Since the mPFC is not a homogenous structure, we attempted to systematically examine the contributionof the different subareas - infralimbic (il), prelimbic (pl), anterior cingulate (cg) - of the mPFC to the induction of sensitization by selectively lesioning these areas or the whole mPFC with quinolinic acid (45 nmol in 0.5 mu l). During an initial habituation session only ii or whole mPFC lesions reduced spontaneous activity. Lesioned and sham-lesioned animals were then treated every other day with either saline, DL amphetamine (3 mg/kg), or cocaine (20 mg/kg) for 2 weeks in their home cages and were then challengedwith either DL-amphetamine (1.5 mg/kg) or cocaine (10 mg/kg) after 1 day and 2 weeks of withdrawal. None of the lesions affected the development of amphetamine induced sensitization in any way, as assessed by several behavioural parameters including locomotion and sniffing. In contrast, cocaine-induced sensitization was significantly attenuated by pl and whole mPFC lesions, while il and cg lesions were without effect. These results show a doubledissociation of the role of the mPFC in behavioural sensitization. The mPFC seems to be important only for cocaine- but not for amphetamine induced sensitization, and only the pl area appears to be of relevance for cocaine induced sensitization. It is suggested that these differences are due to differences in the pharmacological interaction of cocaine and amphetamine withthe mesocortical dopamine system, and to the particular anatomical connections of each of the mPFC subregions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 20:22:00