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Titolo:
Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells
Autore:
Morrione, A; Romano, G; Navarro, M; Reiss, K; Valentinis, B; Dews, M; Eves, E; Rosner, MR; Baserga, R;
Indirizzi:
Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 ay Inst Canc Res, Chicago, IL 60637 USA
Titolo Testata:
CANCER RESEARCH
fascicolo: 8, volume: 60, anno: 2000,
pagine: 2263 - 2272
SICI:
0008-5472(20000415)60:8<2263:IGFIRS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-KINASE; IGF-I; PHOSPHATIDYLINOSITOL 3-KINASE; INSULIN-LIKE-GROWTH-FACTOR-1 RECEPTOR; TRANSDUCTION PATHWAYS; NUCLEAR TRANSLOCATION; TRANSFORMING ACTIVITY; NEUROTROPHIC FACTOR; NEURITE OUTGROWTH; RAF-1 ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Baserga, R Thomas Jefferson Univ, Kimmel Canc Ctr, 233 S 10th St,624 BSLB,Philadelphia, PA 19107 USA Thomas Jefferson Univ 233 S 10th St,624 BSLB Philadelphia PA USA 19107
Citazione:
A. Morrione et al., "Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells", CANCER RES, 60(8), 2000, pp. 2263-2272

Abstract

The type I insulin-like growth factor receptor (IGF-IR) is known to send two seemingly contradictory signals inducing either cell proliferation or cell differentiation, depending on cell type and/or conditions. H19-7 cells are rat hippocampal neuronal cells immortalized by a temperature-sensitive SV40 large T antigen that grow at 34 degrees C in epidermal growth factor orserum but differentiate at 39 degrees C when induced by basic fibroblast growth factor. At 39 degrees C, expression of the human IGF-IR in H19-7 cells induces an insulin-like growth factor (IGF) I-dependent differentiation. We have investigated the domains of the IGF-IR required for differentiationof H19-7 cells. The tyrosine 950 residue and serines 1280-1283 in the COOHterminus of the receptor are required for IGF-I-induced differentiation at39 degrees C, although they are dispensable for IGF-I-mediated growth at 34 degrees C. Both domains have to be mutated to inactivate the differentiating function. The inability of these mutant receptors to induce differentiation correlates with mitogen-activated protein kinase activation. In contrast, inhibitors of phosphatidylinositol 3'-kinase have no effect on IGF-I-mediated differentiation of H19-7 cells, although they do inhibit the mitogenic response.

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Documento generato il 01/12/20 alle ore 22:51:53