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Titolo:
Expression of proteins coincident with inducible radioprotection in human lung epithelial cells
Autore:
Gamble, SC; Dunn, MJ; Wheeler, CH; Joiner, MC; Adu-Poku, A; Arrand, JE;
Indirizzi:
Brunel Univ, Dept Biol Sci, Uxbridge UB8 3PH, Middx, England Brunel Univ Uxbridge Middx England UB8 3PH bridge UB8 3PH, Middx, England Natl Heart & Lung Inst, Imperial Coll Sch Med, Heart Sci Ctr, Dept Cardiothorac Surg, Harefield UB9 6JH, Middx, England Natl Heart & Lung Inst Harefield Middx England UB9 6JH JH, Middx, England Mt Vernon Hosp, Gray Lab, Northwood HA6 2JR, Middx, England Mt Vernon Hosp Northwood Middx England HA6 2JR od HA6 2JR, Middx, England
Titolo Testata:
CANCER RESEARCH
fascicolo: 8, volume: 60, anno: 2000,
pagine: 2146 - 2151
SICI:
0008-5472(20000415)60:8<2146:EOPCWI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-ANALYSIS; LOW-DOSE HYPERSENSITIVITY; KINASE-C SUBSTRATE; HAMSTER V79 CELLS; IONIZING-RADIATION; GENE-EXPRESSION; 2-DIMENSIONAL ELECTROPHORESIS; INDUCED RADIORESISTANCE; ADAPTIVE RESPONSE; STRESS-RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Arrand, JE Brunel Univ, Dept Biol Sci, Uxbridge UB8 3PH, Middx, England Brunel Univ Uxbridge Middx England UB8 3PH 3PH, Middx, England
Citazione:
S.C. Gamble et al., "Expression of proteins coincident with inducible radioprotection in human lung epithelial cells", CANCER RES, 60(8), 2000, pp. 2146-2151

Abstract

Human lung epithelial cells and many other cell lines are hypersensitive to low doses of ionizing radiation (<0.2 Gy), However, above a threshold dose of 0.4-0.6 Gy, an induced radioprotective response is triggered that protects cells at higher radiation doses. At 4 h, when maximal induced radioprotection is seen in these cells after low-dose priming, the two-dimensional gel protein expression pattern in 0.5-Gy-exposed cells is subtly altered, with seven proteins being 2- to 5-fold down-regulated and one being 2-fold up-regulated. They include: (a) the protein kinase C inhibitor 1, or histidine triad nucleotide-binding motif (HINT) protein; (b) substrates for protein kinase C activity including the chloride intracellular channel protein 1:and (c) a cytoskeletal protein degraded during apoptosis, In addition, a lung cancer-specific protein that binds to both telomeres and nascent mRNA molecules is down-regulated, as is interleukin 1 alpha. Therefore, at least in human lung epithelial cells, radioprotection may be the result of signaling pathway switching, which results in the removal of damaged cells and the preparation for enhanced general transcription in surviving cells during a period in which cell proliferation is repressed. This combination of events may be cell-type-specific and may have implications for the protection of normal lung tissue during unavoidable radiation exposure such as in radiotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:23:18