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Titolo:
Increased expression of matrix metalloproteinase 7 and 9 and membrane type1-matrix metalloproteinase in esophageal squamous cell carcinomas
Autore:
Ohashi, K; Nemoto, T; Nakamura, K; Nemori, R;
Indirizzi:
Tokyo Med & Dent Univ, Fac Med, Dept Pathol, Tokyo 113, Japan Tokyo Med & Dent Univ Tokyo Japan 113 Med, Dept Pathol, Tokyo 113, Japan Fuji Photo Film Co Ltd, Ashigara Res Labs, Kanagawa 25001, Japan Fuji Photo Film Co Ltd Kanagawa Japan 25001 Labs, Kanagawa 25001, Japan
Titolo Testata:
CANCER
fascicolo: 10, volume: 88, anno: 2000,
pagine: 2201 - 2209
SICI:
0008-543X(20000515)88:10<2201:IEOMM7>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SANDWICH ENZYME-IMMUNOASSAY; HUMAN GASTRIC CARCINOMAS; MONOCLONAL-ANTIBODIES; IV COLLAGENASE; TISSUE INHIBITOR; MESSENGER-RNA; EXTRACELLULAR-MATRIX; ENHANCED PRODUCTION; SURGICAL-TREATMENT; BREAST CARCINOMAS;
Keywords:
esophagus; squamous cell carcinomas; pathology; invasion; metastasis; extracellular matrix; matrix metalloproteinases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Ohashi, K Tokyo Med & Dent Univ, Fac Med, Dept Pathol, Tokyo 113, Japan Tokyo Med & Dent Univ Tokyo Japan 113 Pathol, Tokyo 113, Japan
Citazione:
K. Ohashi et al., "Increased expression of matrix metalloproteinase 7 and 9 and membrane type1-matrix metalloproteinase in esophageal squamous cell carcinomas", CANCER, 88(10), 2000, pp. 2201-2209

Abstract

BACKGROUND. The 5-year survival rate of patients with submucosal (sm) esophageal carcinoma continues to be much worse than that with intramucosal (m)lesions. The reasons are unclear, but matrix metalloproteinases (MMPs) andmembrane type matrix metalloproteinases (MT-MMPs) are known to be involvedin degradation of extracellular matrix macromolecules associated with tumor cell invasion. Expression of these enzymes may have some relation to the difference in survival between patients with sm and m esophageal carcinomas. METHODS. Surgical specimens from 148 primary esophageal squamous cell carcinomas were examined for expression of MMP-1, 2, 3, 7, and 9; tissue inhibitor of MMP (TIMP)-1 and 2; MT1-MMP; and MT2-MMP by immunohistochemical staining. The results were compared with tumor progression and other clinicopathologic parameters. Localization of gelatinase activity was also confirmed in carcinoma cells by in situ zymography. RESULTS. Expression of MMP-7 and 9, expression of MT1-MMP, and gelatinase activity were elevated in the carcinomas, correlating with depth of tumor invasion. Percentages of positive sm cases were 44.0%, 51.9%, and 52.0%, respectively, significantly higher than for the m cases. Percentages of venousinvasion positive cases were 61.9%, 65.1%, and 65.1%, respectively. CONCLUSIONS. Expression of MMP-7 and 9 and MT1-MMP is closely associated with invasion depth and venous invasion in esophageal squamous cell carcinomas. Cancer 2000;88:2201-9. (C) 2000 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:30:52