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Titolo:
LYMPHOCYTE SUBSET CHANGES BETWEEN 3 AND 15 MONTHS OF AGE IN INFANTS BORN TO HIV-SEROPOSITIVE WOMEN IN SOUTH-AFRICA
Autore:
MOODLEY D; BOBAT RA; COOVADIA HM; DOORASAMY T; MUNSAMY S; GOUWS E;
Indirizzi:
UNIV NATAL,FAC MED,DEPT PAEDIAT & CHILD HLTH,POB 17039 ZA-4013 DURBANSOUTH AFRICA UNIV NATAL,DEPT HEMATOL ZA-4001 DURBAN SOUTH AFRICA MRC,CTR EPIDEMIOL RES DURBAN SOUTH AFRICA
Titolo Testata:
TM & IH. Tropical medicine & international health
fascicolo: 5, volume: 2, anno: 1997,
pagine: 415 - 421
SICI:
1360-2276(1997)2:5<415:LSCB3A>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; INFECTION; CHILDREN; MOTHERS; AIDS;
Keywords:
PERINATAL HIV INFECTION; T-LYMPHOCYTE SUBSETS; DIAGNOSTIC AND PROGNOSTIC MARKERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
D. Moodley et al., "LYMPHOCYTE SUBSET CHANGES BETWEEN 3 AND 15 MONTHS OF AGE IN INFANTS BORN TO HIV-SEROPOSITIVE WOMEN IN SOUTH-AFRICA", TM & IH. Tropical medicine & international health, 2(5), 1997, pp. 415-421

Abstract

The evolution of T-lymphocyte subsets during infancy in perinatally HIV-infected African babies has not been previously described. In a hospital-based cohort study, T-lymphocyte subset changes were investigated in 72 South African black children born to HIV seropositive mothers. Sixteen (22.2%) children were classified as infected and 56 (77.8%) as uninfected by 18 months of age. Four (25%) of the infected infants died before the age of 9 months from HIV-related disease. The CD4 and CD8 T-lymphocyte subsets, expressed in absolute numbers, as percentages, percentiles or as ratios, were clear indicators of HIV infection at all ages between 3 and 15 months. The most marked changes were a decreased percentage of CD4 cells and an increase in percentage of CD8 cells in the infected group. In the 4 infected infants who died, CD8 countand CD4:CD8 ratio clearly predicted poor clinical outcome at 3 months. Taken together, both CD4:CD8 ratio and CD4 percentage are reliable markers of HIV infection in an African paediatric population; however, a raised CD8 lymphocyte count rather than a CD4 count is a more specific prognostic marker of disease progression in HIV infected children.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:26:28