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Titolo:
Neuroleptics ameliorate phencyclidine-induced impairments of short-term memory
Autore:
Schroeder, U; Schroeder, H; Schwegler, H; Sabel, BA;
Indirizzi:
Fac Med, Inst Med Psychol, D-39120 Magdeburg, Germany Fac Med Magdeburg Germany D-39120 ed Psychol, D-39120 Magdeburg, Germany Fac Med, Inst Pharmacol & Toxicol, D-39120 Magdeburg, Germany Fac Med Magdeburg Germany D-39120 & Toxicol, D-39120 Magdeburg, Germany Fac Med, Inst Anat, D-39120 Magdeburg, Germany Fac Med Magdeburg GermanyD-39120 Inst Anat, D-39120 Magdeburg, Germany
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 130, anno: 2000,
pagine: 33 - 40
SICI:
0007-1188(200005)130:1<33:NAPIOS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED STEREOTYPED BEHAVIOR; SOCIAL-INTERACTION TEST; PARKINSONS-DISEASE; PREFRONTAL CORTEX; BASAL GANGLIA; D-AMPHETAMINE; ANIMAL-MODEL; DOPAMINE; SCHIZOPHRENIA; RAT;
Keywords:
binding sites; GABAergic interneurons; haloperidol; phencyclidine; risperidone; short-term memory; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Schroeder, U Fac Med, Inst Med Psychol, Leipziger Str 44, D-39120 Magdeburg, Germany Fac Med Leipziger Str 44 Magdeburg Germany D-39120 , Germany
Citazione:
U. Schroeder et al., "Neuroleptics ameliorate phencyclidine-induced impairments of short-term memory", BR J PHARM, 130(1), 2000, pp. 33-40

Abstract

1 Phencyclidine (PCP), a non-competitive NMDA-receptor antagonist, is ableto induce schizophrenia-like symptoms in animals and in humans. It is known that schizophrenic patients have deficits in memory processes.2 Therefore, it was investigated whether subchronic pulsatile or continuous application of 5.0 mg kg(-1) PCP over 5 days induce short-term memory deficits in holeboard learning and the action of two different neuroleptics onthis behavioural test.3 First, an impairment in the holeboard task was described when the animals were tested 24 h after the last application but not after 15 min or 1 h after the last injection. Secondly, the influence of haloperidol and risperidone on the PCP-induced short-term memory changes was tested.4 The combined application of PCP and risperidone led to a complete antagonism of the shortterm deficits, but the combined treatment with haloperidolwas accompanied by a partial abolishment of the PCP-induced deficits.5 PCP led to an upregulation of the glutamate binding sites in striatum and nucleus accumbens whereas the D-2 binding sites were reduced in striatum. The D-1 binding sites seem to be unchanged. The receptor protein expression of glutamate receptors mGluR1, GluR2, GluR5/7 and NMDAR1 were not modified in response to PCP treatment.6 The determination of a subpopulation of GABAergic interneurons shows a decrease of the cells within the CA3 of the hippocampal formation.7 These findings indicate that PCP induced impairments in short term memory can be detected by holeboard learning and may provide an interesting toolfor the search of new neuroleptics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 17:46:10