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Titolo:
Calpain-mediated truncation of rat brain AMPA receptors increases their Triton X-100 solubility
Autore:
Lu, XY; Rong, YQ; Bi, RF; Baudry, M;
Indirizzi:
Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Program, Los Angeles, CA 90089 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 863, anno: 2000,
pagine: 143 - 150
SICI:
0006-8993(20000428)863:1-2<143:CTORBA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTSYNAPTIC DENSITY PROTEIN; METHYL-D-ASPARTATE; NMDA RECEPTOR; TYROSINE KINASES; ACID RECEPTORS; BINDING-SITES; SUBUNITS; PHOSPHORYLATION; CALMODULIN; GLUR1;
Keywords:
glutamate; receptors; calpain; synapses; plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Baudry, M Univ So Calif, Neurosci Program, Hedco Neurosci Bldg,Rm 309, LosAngeles, CA 90089 USA Univ So Calif Hedco Neurosci Bldg,Rm 309 Los AngelesCA USA 90089
Citazione:
X.Y. Lu et al., "Calpain-mediated truncation of rat brain AMPA receptors increases their Triton X-100 solubility", BRAIN RES, 863(1-2), 2000, pp. 143-150

Abstract

Previous studies have indicated that calpain activation results in the truncation of the C-terminal domains of AMPA and NMDA receptor subunits. The present study determined the distribution of the truncated species of the subunits between Triton-soluble and -insoluble fractions. Western blots were performed with various antibodies to quantify the amounts of the various species of GluR1, GluR2, GluR3 and NR2B subunits. The results indicate that calpain activation decreased the amount of all the intact subunits in Triton-insoluble fractions. Calpain-generated truncated forms of GluR1 and GluR2,but not NR2B, were absent in these fractions, and were recovered in Triton-soluble fractions. These findings suggest that calpain-mediated truncationof AMPA but not NMDA receptor C-terminal domains results in modifications of the interactions between the receptors and postsynaptic densities, and that this mechanism could be involved in activity-dependent changes in the subcellular distribution of AMPA receptors. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 10:44:51