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Titolo:
c-erbB-2 oncoprotein is overexpressed in poorly vascularised squamous cellcarcinomas of the head and neck, but is not associated with response to cytotoxic therapy or survival
Autore:
Giatromanolaki, A; Ourakis, MIK; Sivridis, E; Fountzilas, G;
Indirizzi:
Tumour & Angiogenesis Res Grp, Iraklion 71306, Crete, Greece Tumour & Angiogenesis Res Grp Iraklion Crete Greece 71306 , Crete, Greece Democritus Univ Thrace, Hosp Alexandroupolis, Dept Pathol, Alexandroupolis68100, Greece Democritus Univ Thrace Alexandroupolis Greece 68100 oupolis68100, Greece Univ Hosp Iraklion, Dept Radiotherapy & Oncol, Iraklion 71110, Crete, Greece Univ Hosp Iraklion Iraklion Crete Greece 71110 klion 71110, Crete, Greece Aristotelian Univ Salonika, AHEPA Hosp, Dept Med Oncol, Salonika 54006, Greece Aristotelian Univ Salonika Salonika Greece 54006 Salonika 54006, Greece
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 2A, volume: 20, anno: 2000,
pagine: 997 - 1004
SICI:
0250-7005(200003/04)20:2A<997:COIOIP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; ADVANCED BREAST-CANCER; LUNG-CANCER; PROGNOSTIC VALUE; PREDICTIVE VALUE; EXPRESSION; ONCOGENE; PROTEIN; MARKERS; GENE;
Keywords:
head and neck cancer; angiogenesis c-erbB-2; bcl-2; p53;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Giatromanolaki, A Tumour & Angiogenesis Res Grp, 18 Dimokratias Ave, Iraklion 71306, Crete, Greece Tumour & Angiogenesis Res Grp 18 Dimokratias Ave Iraklion Crete Greece 71306
Citazione:
A. Giatromanolaki et al., "c-erbB-2 oncoprotein is overexpressed in poorly vascularised squamous cellcarcinomas of the head and neck, but is not associated with response to cytotoxic therapy or survival", ANTICANC R, 20(2A), 2000, pp. 997-1004

Abstract

The prognostic and predictive role of c-erbB-2 oncoprotein in human malignancies remains controversial. The pattern of expression, and the biologicalbehavour of c-erbB-2 protein was investigated in a series of 89 locally advanced squamous cat-cinemas of the head and neck. Possible associations between c-erbB-2 and T,N-stage, histological grade, microvessel density and the expression of bcl-2 and p53 proteins were sought. Biopsy material had been collected prior to the initiation of treatment which consisted of platinum based induction chemotherapy ol concurrent chemotherapy and radiotherapy. In all cases, follow-up of at least 2 years duration was available Positive staining was seen in 27 out of 89 (30.4%) cases and was invariably cytoplasmic, exhibiting strong reactivity in more than 50% of tumour cells. Such c-erbB-2 overexpressing tumours were not associated with a response to radiotherapy and/or induction chemotherapy. Further, survival analysis did not disclose any difference in the overall or relapse free survival between c-erbB-2 positive and negative cases. Similarly, no relationship was found with T,N-stage, histological grade and bcl-2 or p53 expression. There was however; a significant inverse association between c-erbB-2 expression and microvessel density (p=0.0001). Interestingly, tumours with low vascular grade (VG; MS<26) and positive c-erbB-2 expression were less frequently associated with local aggressiveness compared to c-erbB-2 negative tumours and low VG (5/27 vs. 12/18; p=0.001), or to c-erbB-2 negative tumours and high VG (MS>27) (5/27 vs. 19/44; p=0.03). These differences were statistically significant but were not related to treatment response ol prognosis. Nonetheless,when patients with highly angiogenic tumours were analysed for survival, irrespective of the c-erbB-2 status, they showed a poorer prognosis than those having a low microvessel density (p=0.06 and 0.05 for overall and relapse free survival, respectively). Six out of 89 patients presented with distant metastases, five of which had tumours negative for c-erbB-2 expression. Our results seem to indicate that the pattern of c-erbB-2 expression in locally advanced inoperable head and neck cancer is exclusively cytoplasmic. c-erbB-2 reactivity is of little value in predicting survival or chemo-radiotherapeutic response. Expression of genes I elated to angiogenesis or otherinvasion and migration pathways are, apparently, more important.

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Documento generato il 03/07/20 alle ore 01:09:11