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Titolo:
Membrane associated antitumor effects of crocine-, ginsenoside- and cannabinoid derivates
Autore:
Molnar, J; Szabo, D; Pusztai, R; Mucsi, I; Berek, L; Ocsovszki, I; Kawata, E; Shoyama, Y;
Indirizzi:
Albert Szent Gyorgyi Med Univ, Fac Med, Inst Microbiol, H-6720 Szeged, Hungary Albert Szent Gyorgyi Med Univ Szeged Hungary H-6720 6720 Szeged, Hungary Albert Szent Gyorgyi Med Univ, Fac Med, Inst Biochem, H-6720 Szeged, Hungary Albert Szent Gyorgyi Med Univ Szeged Hungary H-6720 6720 Szeged, Hungary Kyushu Univ, Dept Pharmacognosy, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812 iv, Dept Pharmacognosy, Fukuoka 812, Japan
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 2A, volume: 20, anno: 2000,
pagine: 861 - 867
SICI:
0250-7005(200003/04)20:2A<861:MAAEOC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SAFFRON CROCUS-SATIVUS; SKIN TUMOR PROMOTION; ANTIGEN EXPRESSION; BENZOPHENOTHIAZINES; INHIBIT; CROCETIN; CELLS; MICE;
Keywords:
multidrug resistance; tumor antigen; immunomodulation; crocine ginzenoside; cannabinoid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Molnar, J Albert Szent Gyorgyi Med Univ, Fac Med, Inst Microbiol, Dom Ter 10, H-6720Szeged, Hungary Albert Szent Gyorgyi Med Univ Dom Ter 10 Szeged Hungary H-6720
Citazione:
J. Molnar et al., "Membrane associated antitumor effects of crocine-, ginsenoside- and cannabinoid derivates", ANTICANC R, 20(2A), 2000, pp. 861-867

Abstract

In the present work a systematic study was initiated with crocine, ginsenoside and cannabinoid derivatives on multidrug resistant mouse lymphoma cells, vir al tumor antigen expression and some human leukocyte functions. Among saffron derivatives crocin and picrocrocin, triglucosyl and diglucosyl crocetin were ineffective on the reversal of multidrug resistance of lymphomacells. Ginsenoside inn-eased drug accumulation and tumor antigen expression at 2.0-20.0 mu g/mL. Some cannabinoid derivatives such as cannabinol, cannabispirol and cannabidiol increased drug accumulation while cannabidiolic acid, delta-9-THC and tetrahydro-cannabidiolic acid reduced drug accumulation of the human mdr1-gene transfected mouse lymphoma cells. The reversal ofmultidrug resistance is the result of the inhibition of the efflux pump function in the tumor cells. Crocetin eaters were less potent than crocin itself in the inhibition of EBV early antigen expression. However crocin and diglucosyl-crocetin inhibited early tumor antigen expression of adenovirus infected cells, but triglucosylcrocetin was less effective at 0.01-1.0 mu g/mL. The crocin had no antiviral effect [on HSV-2 infected vero cells] rep to 25 mu g/mL concentration. Ginsenosides had a moderate inhibitory effect except ginsenoside Rb1 (was the less effective) on the drug efflux pump. Among the cannabinoid derivatives the cannabinol and cannabispirol increased drug accumulation, while cannabidiolic acid and delta-9-THC, delta-9-THC andtetrahydro- cannabinol reduced drug accumulation in multidrug resistant mouse lymphoma cells. It is interesting that ginsenosides had a chemical structure-dependent immunomodulating effect by enhancing the activity of NK-cells and ADCC activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:15:16