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Titolo:
Immunocytochemical detection of hMSH2 and hMLH1 expression in oral melanoma
Autore:
Lo Muzio, L; Nocini, P; Mignogna, MD; Pannone, G; Staibano, S; Procaccini, M; Rubini, C; Fioroni, M; Fanali, S; Piattelli, A;
Indirizzi:
Univ Naples Federico II, Fac Med & Surg, Dept Oral Med & Pathol, Naples, Italy Univ Naples Federico II Naples Italy t Oral Med & Pathol, Naples, Italy Univ Verona, Fac Med & Surg, Div Oral Surg, I-37100 Verona, Italy Univ Verona Verona Italy I-37100 g, Div Oral Surg, I-37100 Verona, Italy Univ Naples Federico II, Fac Med & Surg, Pathol Unit, Dept Biomorphol & Funct Sci, Naples, Italy Univ Naples Federico II Naples Italy morphol & Funct Sci, Naples, Italy Univ Ancona, Fac Med & Surg, Inst Dent Sci, Ancona, Italy Univ Ancona Ancona Italy , Fac Med & Surg, Inst Dent Sci, Ancona, Italy Univ Ancona, Fac Med & Surg, Inst Pathol Anat & Histopathol, Ancona, ItalyUniv Ancona Ancona Italy Inst Pathol Anat & Histopathol, Ancona, Italy Univ Ancona, Fac Med & Surg, Dept Oral Med & Pathol, Ancona, Italy Univ Ancona Ancona Italy & Surg, Dept Oral Med & Pathol, Ancona, Italy Univ Chieti, Fac Med & Surg, Dept Dent Sci, Chieti, Italy Univ Chieti Chieti Italy , Fac Med & Surg, Dept Dent Sci, Chieti, Italy
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 2A, volume: 20, anno: 2000,
pagine: 741 - 748
SICI:
0250-7005(200003/04)20:2A<741:IDOHAH>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPOLYPOSIS COLORECTAL-CANCER; MISMATCH REPAIR GENES; NUCLEOTIDE-EXCISION-REPAIR; CARCINOMA CELL-LINES; MICROSATELLITE INSTABILITY; DNA-MISMATCH; COLON-CANCER; CUTANEOUS MELANOMA; MALIGNANT-MELANOMA; MUTATOR PHENOTYPE;
Keywords:
hMSH2; hMLH1; melanoma; oral; head and neck;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Lo Muzio, L Via Carelli 28, I-71100 Foggia, Italy Via Carelli 28 Foggia Italy I-71100 8, I-71100 Foggia, Italy
Citazione:
L. Lo Muzio et al., "Immunocytochemical detection of hMSH2 and hMLH1 expression in oral melanoma", ANTICANC R, 20(2A), 2000, pp. 741-748

Abstract

Background: The DNA mismatch repair system (MMR) plays an important role in the maintenance of genomic stability. To date few studies have been performed on hMSH2 and hMLH1 expression and melanoma of the head and neck region. A study of two cases revealed no mutations of the mismatch repair genes hMSH2 and hMLH1. Materials and Methods: To verify the possibility of implication of hMSH2 and hMLH2 alterations in melanocytic cancerogenesis, the authors examined the protein expression pattern of hMSH2 and hMLH1 by immunohistochemistry in 9 paraffin-embedded oral melanoma. Results: One case (11%) showed nuclear positivity for hMSH2, 3 cases (33%) showed cytoplasmic positivity, and five cases (55%) showed no staining in the tumoral cells, even ifnormal squamous epithelium available in this section showed a nuclear positivity. Four cases (44%) showed no hMLH1 staining in the tumoral cells, even if normal squamous epithelium available in this section showed a nuclear positivity. Two cases (22%) showed nuclear positivity, and three cases (33%) showed cytoplasmic positivity. Conclusions: The analysis of mismatch repair genes can be a new molecular diagnostic tools for the detection of patients at high risk of developing melanoma and other neoplasia, or metastasis and recurrences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 15:56:13