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Titolo:
An association between migraine and cutaneous allodynia
Autore:
Burstein, R; Yarnitsky, D; Goor-Aryeh, I; Ransil, BJ; Bajwa, ZH;
Indirizzi:
Harvard Univ, Inst Med,Med Sch, Beth Israel Deaconess Med Ctr, Dept Anesthesia & Crit Care, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 thesia & Crit Care, Boston, MA 02115 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston,MA 02115 USA Harvard Univ Boston MA USA 02115 ed Ctr, Dept Neurol, Boston,MA 02115 USA Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Neurobiol, Boston, MA 02115 USA Harvard Univ, Sch Med, Neurosci Program, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 , Neurosci Program, Boston, MA 02115 USA
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 5, volume: 47, anno: 2000,
pagine: 614 - 624
SICI:
0364-5134(200005)47:5<614:AABMAC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TENSION-TYPE HEADACHE; PRESSURE PAIN THRESHOLDS; MUSCLE TENDERNESS; COMMON MIGRAINE; PERICRANIAL TENDERNESS; NEURONS; RAT; STIMULATION; RESPONSES; RESPONSIVENESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Burstein, R Harvard Univ, Inst Med,Med Sch, Beth Israel Deaconess Med Ctr,Dept Anesthesia & Crit Care, Room 830,77 Ave Louis Pasteur, Boston, MA 02115 USA Harvard Univ Room 830,77 Ave Louis Pasteur Boston MA USA 02115
Citazione:
R. Burstein et al., "An association between migraine and cutaneous allodynia", ANN NEUROL, 47(5), 2000, pp. 614-624

Abstract

Recent animal studies on the mechanism of migraine show that intracranial pain is accompanied by increased periorbital skin sensitivity. These findings suggest that the pathophysiology of migraine involves not only irritation of meningeal perivascular pain fibers but also a transient increase in the responsiveness (ie, sensitization) of central pain neurons that process information arising from intracranial structures and skin. The purpose of this study was to determine whether the increased skin sensitivity observed in animal also develops in humans during migraine attacks, Repeated measurements of mechanical and thermal pain thresholds of periorbital and forearm skin areas in the absence of, and during, migraine attacks enabled us to determine the occurrence of cutaneous allodynia during migraine. Cutaneous allodynia is pain resulting from a nonnoxious stimulus to normal skin. In 79% of the patients, migraine was associated with cutaneous allodynia as defined, and in 21% of the patients it was not. The cutaneous allodynia occurred either solely within the referred pain area on the ipsilateral head, or within and outside the ipsilateral head. Cutaneous allodynia in certain well-defined regions of the skin during migraine is an as yet unreported neurological finding that points to hyperexcitability of a specific central pain pathway that subserves intracranial sensation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:05:43