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Titolo:
Transient pituitary hypothyroidism in a patient with ectopic adrenocorticotrophic hormone secretion
Autore:
Rodriguez-Espinosa, J; Urgell, E; Montesinos, J; Domingo, P; Webb, SM;
Indirizzi:
Autonomous Univ Barcelona, Hosp Santa Creu & Sant Pau, Clin Biochem Serv, Barcelona 08025, Spain Autonomous Univ Barcelona Barcelona Spain 08025 , Barcelona 08025, Spain Autonomous Univ Barcelona, Hosp Santa Creu & Sant Pau, Oncol Serv, Barcelona 08025, Spain Autonomous Univ Barcelona Barcelona Spain 08025 , Barcelona 08025, Spain Autonomous Univ Barcelona, Hosp Santa Creu & Sant Pau, Internal Med Serv, Barcelona 08025, Spain Autonomous Univ Barcelona Barcelona Spain 08025 , Barcelona 08025, Spain Autonomous Univ Barcelona, Hosp Santa Creu & Sant Pau, Serv Endocrinol, Barcelona 08025, Spain Autonomous Univ Barcelona Barcelona Spain 08025 , Barcelona 08025, Spain
Titolo Testata:
ANNALS OF CLINICAL BIOCHEMISTRY
, volume: 37, anno: 2000,
parte:, 3
pagine: 298 - 303
SICI:
0004-5632(200005)37:<298:TPHIAP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
EUTHYROID SICK SYNDROME; THYROTROPIN-RELEASING-HORMONE; NONTHYROIDAL ILLNESS; POSTMENOPAUSAL WOMEN; SERUM INTERLEUKIN-6; THYROID-FUNCTION; TSH SECRETION; ADRENAL AXIS; HYPOTHYROXINEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Rodriguez-Espinosa, J Autonomous Univ Barcelona, Hosp Santa Creu & Sant Pau, Clin Biochem Serv, Avda S Antoni M Claret 167, Barcelona 08025, Spain Autonomous Univ Barcelona Avda S Antoni M Claret 167 Barcelona Spain 08025
Citazione:
J. Rodriguez-Espinosa et al., "Transient pituitary hypothyroidism in a patient with ectopic adrenocorticotrophic hormone secretion", ANN CLIN BI, 37, 2000, pp. 298-303

Abstract

We report the case of a 55-year-old woman who presented with hypercortisolism secondary to ectopic adrenbcorticotrophic hormone secretion and severe non-thyroidal illness syndrome (NTIS) due to metastatic small cell lung carcinoma associated with severe infections. The patient initially showed hormonal profiles of pituitary hypothyroidism and gonadal hypofunction. After decrease in cortisol production following treatment with chemotherapy and metyrapone, serum thyroid hormones and thyroid-stimulating hormone (TSH) concentrations normalized. Study of the: relative contributions of cortisol andpro-inflammatory cytokines (interleukin-6 and tumour necrosis factor alpha) to the overall variability in thyroid function tests disclosed a significant and independent effect of serum cortisol on serum TSH concentrations: the variability in free thyroid hormone concentration was explained only by changes in TSH concentration. These observations indicate that cortisol could be the major determinant of changes in serum TSH concentrations in clinical conditions accompanied by hypercortisolism, as occurs in NTIS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:46:26