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Titolo:
A prospective, randomized study of goal-oriented hemodynamic therapy in cardiac surgical patients
Autore:
Polonen, P; Ruokonen, E; Hippelainen, M; Poyhonen, M; Takala, J;
Indirizzi:
Kuopio Univ Hosp, Dept Anesthesia & Intens Care, Crit Care Res Program, FIN-70211 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland FIN-70211 ram, FIN-70211 Kuopio, Finland Kuopio Univ Hosp, Dept Surg, Crit Care Res Program, FIN-70211 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland FIN-70211 ram, FIN-70211 Kuopio, Finland
Titolo Testata:
ANESTHESIA AND ANALGESIA
fascicolo: 5, volume: 90, anno: 2000,
pagine: 1052 - 1059
SICI:
0003-2999(200005)90:5<1052:APRSOG>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRITICALLY ILL PATIENTS; PERIPHERAL VASCULAR-SURGERY; MAXIMIZING OXYGEN DELIVERY; PROLONGED INTENSIVE-CARE; PREOPERATIVE OPTIMIZATION; CLINICAL-TRIAL; END-POINTS; CONSUMPTION; RISK; RESUSCITATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Polonen, P Kuopio Univ Hosp, Dept Anesthesia & Intens Care, Crit Care Res Program, FIN-70211 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland FIN-70211 211 Kuopio, Finland
Citazione:
P. Polonen et al., "A prospective, randomized study of goal-oriented hemodynamic therapy in cardiac surgical patients", ANESTH ANAL, 90(5), 2000, pp. 1052-1059

Abstract

Organ dysfunction and multiple organ failure are the main causes of prolonged hospital stay after cardiac surgery, which increases resource use and health care costs, increased levels of oxygen delivery and consumption are associated with improved outcome in different groups of postoperative patients. Cardiac surgical patients are at risk of inadequate perioperative oxygen delivery caused by extracorporeal circulation and limited cardiovascular reserves. The purpose of our study was to test whether increasing oxygen delivery immediately after cardiac surgery would shorten hospital and intensive care unit (ICU) stay. Four hundred three elective cardiac surgical patients were enrolled in the study and randomly assigned to either the control or the protocol group. Goals of the protocol group were to maintain Svo(2) >70% and lactate concentration less than or equal to 2.0 mmol/L from admission to the ICU and up to 8 h thereafter. Hemodynamics, oxygen transport data, and organ dysfunctions were recorded. The median hospital stay was shorter in the protocol group (6 vs 7 days, P < 0.05), and patients were discharged faster from the hospital than those in the control group (P < 0.05). Discharge from the ICU was similar between. groups (p = 0.8). Morbidity was less frequent at the time of hospital discharge in the protocol group (1.1% vs 6.1%, P < 0.01). Increasing oxygen delivery to achieve normal Svo(2) values and lactate concentration during the immediate postoperative period after cardiac surgery can shorten the length of hospital stay.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:34:27