Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Clinicopathologic reassessment of primary cutaneous B-cell lymphomas with immunophenotypic and molecular genetic characterization
Autore:
Yang, B; Tubbs, RR; Finn, W; Carlson, A; Pettay, J; Hsi, ED;
Indirizzi:
Cleveland Clin Fdn, Dept Clin Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 Pathol, Cleveland, OH 44195 USA Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Pathol, Ann Arbor, MI 48109 USA Albany Med Coll, Albany, NY 12208 USA Albany Med Coll Albany NY USA 12208Albany Med Coll, Albany, NY 12208 USA
Titolo Testata:
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
fascicolo: 5, volume: 24, anno: 2000,
pagine: 694 - 702
SICI:
0147-5185(200005)24:5<694:CROPCB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; EUROPEAN-AMERICAN CLASSIFICATION; BCL-6 PROTEIN EXPRESSION; TREATMENT-OF-CANCER; FOLLICULAR LYMPHOMA; EORTC CLASSIFICATION; 14-18 TRANSLOCATION; EMBEDDED SECTIONS; REARRANGEMENTS; HYPERPLASIA;
Keywords:
primary cutaneous B-cell lymphoma; follicle center lymphoma; diffuse large B-cell lymphoma; marginal zone B-cell lymphoma; Bcl-2; Bcl-6; t(14;18); gene rearrangement;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hsi, ED Cleveland Clin Fdn, Dept Clin Pathol, 9500 Euclid Ave, Cleveland, OH 44195USA Cleveland Clin Fdn 9500 Euclid Ave Cleveland OH USA 44195 44195USA
Citazione:
B. Yang et al., "Clinicopathologic reassessment of primary cutaneous B-cell lymphomas with immunophenotypic and molecular genetic characterization", AM J SURG P, 24(5), 2000, pp. 694-702

Abstract

Primary cutaneous B-cell lymphomas (PCBLs) may have particular. clinicopathologic characteristics distinct from their lymph node-based counterparts. It has been suggested that PCBLs should have a separate classification system. The aim of this study was to determine whether the Revised European-American Lymphoid Neoplasms (REAL) classification is applicable to PCBL. Thirty nine cases of PCBL from 36 patients, consisting of 20 men and 16 women (median age 66 yrs), were included in this study. Paraffin-section immunohistochemistry for CD3, CD5, CD10, CD20, CD43, Bcl-2, Bcl-6, and cyclin D1 was performed in all cases. Immunostaining for immunoglobulin light chains was also performed on cases histologically diagnosed as extranodal marginal zone lymphoma (MZL) and primary cutaneous B-cell lymphoma unclassifiable (PCBLu). Polymerase chain reaction (PCR) analysis of t(14;18) was performed in all cases. Immunoglobulin heavy chain gene rearrangement (VDJ) was tested byPCR on all follicle center lymphoma (FCL), MZL, and PCBLu cases. The 39 cases consisted of 15 (39%) FCLs, 13 (33%) diffuse large B-cell lymphomas (DLCL), 9 (23%) extranodal MZL, and 2 cases of PCBLu. Anatomically, 59% of PCBLs occurred in the head and neck, of which approximately 57% were FCL. Fiveof six cases presenting on the lower extremity were DLCL. Follow-up data was available from all 39 patients with a mean of 50.8 months. All but two patients are alive with or without disease at last contact. One patient withDLCL died of lung metastases and the other DLCL patient died of sepsis as a complication of therapy. In all 15 cases of FCL, CD10 and/or Bcl-6 expression supported the follicle center origin of the neoplastic cells. In contrast to previous reports, we found that 53% (8 of 15) of primary cutaneous FCL had either Bcl-2 protein expression or t(14;18). Our data indicate that many cases of primary cutaneous FCL have Bcl-2 alterations similar to theirnodal counterpart. We found that 95% (37 of 39) of PCBLs could be classified according to the REAL classification, supporting its applicability in cutaneous lymphomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 23:37:59