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Titolo:
Normal P50 suppression in schizophrenia patients treated with atypical antipsychotic medications
Autore:
Light, GA; Geyer, MA; Clementz, BA; Cadenhead, KS; Braff, DL;
Indirizzi:
Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 5, volume: 157, anno: 2000,
pagine: 767 - 771
SICI:
0002-953X(200005)157:5<767:NPSISP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORY GATING DEFICITS; NEUROPHYSIOLOGICAL EVIDENCE; STIMULATION INTERVAL; STARTLE REFLEX; ANIMAL-MODEL; AUDITORY P50; AMPHETAMINE; RELATIVES; CLOZAPINE; NORMALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Braff, DL Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 93 USA
Citazione:
G.A. Light et al., "Normal P50 suppression in schizophrenia patients treated with atypical antipsychotic medications", AM J PSYCHI, 157(5), 2000, pp. 767-771

Abstract

Objective: Patients with schizophrenia have deficits in attention, cognition, and information processing. Measures such as P50 suppression are used to study cognitive and attentional dysfunction among these patients. P50 suppression is an operational measure of sensory gating that can be assessed by averaging electroencephalographic responses to multiple pairs of auditoryclicks separated by 500 msec. Normally, the P50 response to the second click is smaller than the response to the first click. Many studies have demonstrated that schizophrenia patients have deficient P50 suppression, meaningthat the difference between the first and second clicks is not as large asnormal. Atypical antipsychotic medications may have superior clinical efficacy for negative symptoms and cognitive deficits. It is important, therefore, to evaluate the effects of atypical antipsychotic medications on measures such as P50 suppression. Method: P50 suppression of 13 patients with schizophrenia receiving clinically effective doses of clozapine, olanzapine, or risperidone (classified as atypical antipsychotic medications) was compared to that of 13 patients receiving conventional antipsychotic medications. Results: The patient groups did not differ on clinical or demographic measures. The patients receiving atypical antipsychotic medications had normal-range P50 suppression (mean=72%). In contrast, the patients receiving typical antipsychotic medications had dramatically lower P50 suppression (mean= 27%). Conclusions: The results support the hypothesis that patients treated withatypical antipsychotic medications have normal P50 measures of sensory gating. Longitudinal within-subjects studies are warranted to clarify the mechanisms mediating this effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:24:18