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Titolo:
Hippocampal volume in adolescent-onset alcohol use disorders
Autore:
De Bellis, MD; Clark, DB; Beers, SR; Soloff, PH; Boring, AM; Hall, J; Kersh, A; Keshavan, MS;
Indirizzi:
Univ Pittsburgh, Western Psychiat Inst & Clin, Med Ctr, Dev Traumatol Neuroimaging Lab, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 ing Lab, Pittsburgh, PA 15213 USA Western Psychiat Inst & Clin, Adolescent Alchol Res Ctr, Pittsburgh, PA 15213 USA Western Psychiat Inst & Clin Pittsburgh PA USA 15213 sburgh, PA 15213 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 5, volume: 157, anno: 2000,
pagine: 737 - 744
SICI:
0002-953X(200005)157:5<737:HVIAAU>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; SCHOOL-AGE-CHILDREN; PSYCHIATRIC-DIAGNOSIS; BRAIN-DEVELOPMENT; CUSHINGS-SYNDROME; QUANTITATIVE MRI; ETHANOL EXPOSURE; TEMPORAL-LOBE; GRAY-MATTER; DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: De Bellis, MD Univ Pittsburgh, Western Psychiat Inst & Clin, Med Ctr, Dev Traumatol Neuroimaging Lab, 3811 Ohara St, Pittsburgh, PA 15213 USA Univ Pittsburgh 3811 Ohara St Pittsburgh PA USA 15213 13 USA
Citazione:
M.D. De Bellis et al., "Hippocampal volume in adolescent-onset alcohol use disorders", AM J PSYCHI, 157(5), 2000, pp. 737-744

Abstract

Objective: Alcohol use disorders (defined as DSM-IV alcohol dependence or abuse) are prevalent and serious problems among adolescents. As adolescenceis marked by progressive hippocampal development, this brain region may beparticularly susceptible to the adverse effects of adolescent alcohol use disorders. This study compared the hippocampal volumes of adolescents and young adults with adolescent-onset alcohol use disorders to those of healthymatched comparison subjects. Method: Magnetic resonance imaging was used to measure the hippocampal volumes and volumes of comparison brain regions in 12 subjects with alcohol use disorders and 24 comparison subjects matched on age, sex, and handedness. Results: Both left and right hippocampal volumes were significantly smaller in subjects with alcohol use disorders than in comparison subjects. Totalhippocampal pal volume correlated positively with the age at onset and negatively with the duration of the alcohol use disorder, intracranial, cerebral, and cortical gray and white matter Volumes and measures of the mid-sagittal area of the corpus callosum did not differ between groups. Conclusions: In the mature brain, chronic alcohol use disorders are associated with graded global brain dysmorphology. Although the etiology, neuropsychological consequences, and permanence of these hippocampal findings needto be further examined, these findings suggest that, during adolescence, the hippocampus may be particularly susceptible to the adverse effects of alcohol.

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Documento generato il 20/01/21 alle ore 04:36:35