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Titolo:
Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia
Autore:
Freedman, R; Adams, CE; Adler, LE; Bickford, PC; Gault, J; Harris, JG; Nagamoto, HT; Olincy, A; Ross, RG; Stevens, KE; Waldo, M; Leonard, S;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 tr, Dept Psychiat, Denver, CO 80262 USA Denver VA Med Ctr Schizophrenia Res Ctr, Denver, CO USA Denver VA Med Ctr Schizophrenia Res Ctr Denver CO USA tr, Denver, CO USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 1, volume: 97, anno: 2000,
pagine: 58 - 64
SICI:
0148-7299(200021)97:1<58:INDAAP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-BUNGAROTOXIN-BINDING; SENSORY GATING DEFICITS; REPEATED AUDITORY-STIMULI; RAT HIPPOCAMPUS; EVOKED-RESPONSE; P50 SUPPRESSION; CHROMOSOME-15 LOCUS; ONSET SCHIZOPHRENIA; CIGARETTE-SMOKING; LINKAGE ANALYSIS;
Keywords:
schizophrenia; genetics; nicotinic receptors; inhibition; auditory evoked potential;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Freedman, R Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Campus Box C-268-71,4200 E 9thAve, Denver, CO 80262 USA Univ Colorado Campus Box C-268-71,4200 E 9th Ave Denver CO USA 80262
Citazione:
R. Freedman et al., "Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia", AM J MED G, 97(1), 2000, pp. 58-64

Abstract

Many investigators have proposed that biological endophenotypes might facilitate the genetic analysis of schizophrenia. A deficit in the inhibition of the P50 evoked response to repeated auditory stimuli has been characterized as a neurobiological deficit in schizophrenia. This deficit is linked toa candidate gene locus, the locus of the alpha 7-nicotinic cholinergic receptor subunit gene on chromosome 15q14. Supportive evidence has been found by other investigators, including: 1) linkage of schizophrenia to the same locus, 2) linkage of bipolar disorder to the locus; and 3) replication of the existence of this neurobiological deficit and its relation to broader neuropsychological deficits in schizophrenia. It is certain that there are many genetic factors in schizophrenia and bipolar disorder; what is needed isa complete and precise description of the contribution of each individual factor to the pathophysiology of these illnesses. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 26/01/20 alle ore 17:19:55