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Titolo:
Triple therapy for acute myocardial infarction: Combining fibrinolysis, platelet IIb/IIIa inhibition, and percutaneous coronary intervention
Autore:
Herrmann, HC;
Indirizzi:
Univ Penn, Med Ctr, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 , Med Ctr, Philadelphia, PA 19104 USA
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 8A, volume: 85, anno: 2000,
pagine: 10C - 16C
SICI:
0002-9149(20000427)85:8A<10C:TTFAMI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE-PLASMINOGEN-ACTIVATOR; PRIMARY ANGIOPLASTY; RECEPTOR BLOCKADE; THROMBOLYTIC THERAPY; IMMEDIATE ANGIOPLASTY; BALLOON ANGIOPLASTY; RANDOMIZED TRIAL; ABCIXIMAB; INTEGRIN; ARTERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Herrmann, HC Hosp Univ Penn, 3400 Spruce St,9 Founders Pavil, Philadelphia, PA 19104 USA Hosp Univ Penn 3400 Spruce St,9 Founders Pavil Philadelphia PA USA 19104
Citazione:
H.C. Herrmann, "Triple therapy for acute myocardial infarction: Combining fibrinolysis, platelet IIb/IIIa inhibition, and percutaneous coronary intervention", AM J CARD, 85(8A), 2000, pp. 10C-16C

Abstract

Reperfusion for acute myocardial infarction (MI) has generally been approached in 1 of 2 ways-fibrinolysis or primary angioplasty, Although fibrinolysis is widely available and has been shown to reduce mortality and improve left ventricular function, its disadvantages include hemorrhage, failure toreperfuse in vp to 40% of patients, and early reocclusion in up to 10% of patients. Alternatively, primary angioplasty offers the advantages of anatomic definition, the potential for higher rates of reperfusion, and a lower rate of intracranial hemorrhage, Recently, a better understanding of platelet physiology and its inhibition, and advances in mechanical revascularization with stents have led to combined approaches (fibrinolytic agents, glycoprotein IIb/IIIa inhibitors, and percutaneous coronary interventions [PCI]), Faciliated PCI, the use of planned PCI after pharmacologic reperfusion therapy, has the best potential to fuse the best aspects of thrombolysis and primary angioplasty, This article reviews recent advances and trials studying use of these combinations, (C) 2000 by Excerpta Medico, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 03:02:59