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Titolo:
Review article: cyclooxygenase - a target for colon cancer prevention
Autore:
Dubois, RN;
Indirizzi:
Vanderbilt Univ, Med Ctr, Vet Affairs Med Ctr, Dept Med, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Dept Med, Nashville, TN 37232 USA Vanderbilt Univ, Med Ctr, Vet Affairs Med Ctr, Dept Cell Biol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Cell Biol, Nashville, TN 37232 USA
Titolo Testata:
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
, volume: 14, anno: 2000, supplemento:, 1
pagine: 64 - 67
SICI:
0269-2813(200004)14:<64:RAC-AT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; FAMILIAL ADENOMATOUS POLYPOSIS; PROSTAGLANDIN G/H SYNTHASE-1; APOPTOSIS; SULINDAC; CELLS; INHIBITION; GENE; CHEMOPREVENTION; OVEREXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Dubois, RN Vanderbilt Univ, Med Ctr, Dept Med GI, MCN C-2104, Nashville, TN 37232 USA Vanderbilt Univ MCN C-2104 Nashville TN USA 37232 TN 37232 USA
Citazione:
R.N. Dubois, "Review article: cyclooxygenase - a target for colon cancer prevention", ALIM PHARM, 14, 2000, pp. 64-67

Abstract

Use of nonsteroidal anti-inflammatory drugs such as aspirin, which are known to inhibit cyclooxygenase activity, reduces the relative risk of colorectal cancer in humans by 40-50%. Animal and human studies have shown a 50-80% reduction in tumour multiplicity following treatment with a variety of nonsteroidal antiinflammatory drugs. Two isoforms of cyclooxygenase have beendescribed, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). In 85% of colorectal adenocarcinomas taken from humans, COX-2 levels are 2-50-fold higher than levels in adjacent normal intestinal mucosa, while COX-1 levelsare unchanged. These observations raise the question: Does COX-1 or COX-2 provide a useful target for prevention or treatment of colorectal cancer?

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Documento generato il 02/07/20 alle ore 18:02:31