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Titolo:
Biologic and clinical significance of HER-2/neu (cerbB-2) in breast cancer
Autore:
Sahin, AA;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 c Ctr, Dept Pathol, Houston, TX 77030 USA
Titolo Testata:
ADVANCES IN ANATOMIC PATHOLOGY
fascicolo: 3, volume: 7, anno: 2000,
pagine: 158 - 166
SICI:
1072-4109(200005)7:3<158:BACSOH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-RECEPTOR; CARCINOMA IN-SITU; C-ERBB-2 ONCOPROTEIN EXPRESSION; HER2/NEU-OVEREXPRESSING METASTATIC BREAST; EXTRAMAMMARY PAGETS-DISEASE; PROTEIN OVER-EXPRESSION; LYMPH-NODE METASTASES; LONG-TERM SURVIVAL; S-PHASE FRACTION; PROGNOSTIC-SIGNIFICANCE;
Keywords:
breast cancer; HER-2/neu (cerbB-2); oncogene expression; prognostic marker; predictive marker;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
115
Recensione:
Indirizzi per estratti:
Indirizzo: Sahin, AA Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Box 085,1515 Holcombe Blvd,Houston, TX 77030 USA Univ Texas Box 085,1515 Holcombe Blvd Houston TX USA 77030 0 USA
Citazione:
A.A. Sahin, "Biologic and clinical significance of HER-2/neu (cerbB-2) in breast cancer", ADV ANAT PA, 7(3), 2000, pp. 158-166

Abstract

HER-2/neu (aIso known as c-erbB-2) oncogene is a member of the epidermal growth factor receptor family and its amplification is one of the most common genetic alterations associated with human breast cancer. Preclinical studies have suggested that HER-2/neu overexpression enhances metastatic potential of breast cancer cells. Although some discrepancies exist in clinical studies, in general, HER-2/neu amplification is found to be associated with more aggressive clinicopathologic features. HER-2/neu amplification is alsoassociated with drug resistance or sensitivity to specific chemotherapy and hormonal therapy regimens. Advances in breast cancer therapies in recent years have moved towards the development of tumor-specific targeted therapies. Monoclonal antibodies directed against HER-2/neu have been developed and used in clinical practice. These developments necessitate a reliable assay for assessment of HER-2/neu. This article is a review of biologic and clinical significance of HER-2/neu and summarizes HER-2/neu detection methods.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 05:57:39