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Titolo:
Transhepatic neutrophil and monocyte activation during clinical liver transplantation
Autore:
Pesonen, EJ; Hockerstedt, K; Makisalo, H; Vuorte, J; Jansson, SE; Orpana, A; Karonen, SL; Repo, H;
Indirizzi:
Univ Helsinki, Cent Hosp, Hosp Children & Adolescents, Dept Anesthesiol & Intens Care Med, FIN-00290 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00290 ed, FIN-00290 Helsinki, Finland Univ Helsinki, Cent Hosp, Dept Surg 4, FIN-00290 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00290 4, FIN-00290 Helsinki, Finland Univ Helsinki, Cent Hosp, Dept Internal Med, FIN-00290 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00290 ed, FIN-00290 Helsinki, Finland Univ Helsinki, Cent Hosp, Div Infect Dis, FIN-00290 Helsinki, Finland UnivHelsinki Helsinki Finland FIN-00290 is, FIN-00290 Helsinki, Finland Univ Helsinki, Cent Hosp, Dept Clin Chem, FIN-00290 Helsinki, Finland UnivHelsinki Helsinki Finland FIN-00290 em, FIN-00290 Helsinki, Finland
Titolo Testata:
TRANSPLANTATION
fascicolo: 7, volume: 69, anno: 2000,
pagine: 1458 - 1464
SICI:
0041-1337(20000415)69:7<1458:TNAMAD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA-REPERFUSION INJURY; NECROSIS-FACTOR-ALPHA; RAT-LIVER; HEPATIC ISCHEMIA; LEUKOCYTE ADHESION; ICAM-1 EXPRESSION; TNF-ALPHA; ENDOTOXIN; BLOOD; ALLOGRAFTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Pesonen, EJ Univ Helsinki, Cent Hosp, Hosp Children & Adolescents, Dept Anesthesiol & Intens Care Med, Stenbackinkatu 11, FIN-00290 Helsinki, FinlandUniv Helsinki Stenbackinkatu 11 Helsinki Finland FIN-00290 nd
Citazione:
E.J. Pesonen et al., "Transhepatic neutrophil and monocyte activation during clinical liver transplantation", TRANSPLANT, 69(7), 2000, pp. 1458-1464

Abstract

Background. During experimental liver transplantation, neutrophil sequestration results in increased oxygen free radical production and correlates inversely with graft viability. Neutrophil activation in clinical liver transplantation is poorly understood. Methods. We assessed leukocyte sequestration and transhepatic differences of neutrophil and monocyte CD11b expression, neutrophil free radical production, and plasma concentrations of interleukin 6 and interleukin 8 in nine patients during liver transplantation. Results. Significant hepatic neutrophil sequestration occurred during initial graft rewarming with portal blood, after inferior vena cava declamping,and after hepatic artery declamping (all P<0.05). A positive transhepatic difference (i.e., outcoming - ingoing) in CD11b expression of neutrophils was observed after portal vein declamping (51+/-32 relative fluorescence unit [RFU]) and in CD11b expression of monocytes during initial graft rewarming (67+/-86 RFU, both P<0.05). A transcoronary increase in both unstimulated(74+/-80 RFU) and N-formyl-methionyl-leucyl-phenylalanine-stimulated (112+/-168 RFU) neutrophil free radical production took place after hepatic artery declamping (both P<0.05). A negative transcoronary difference of interleukin 6 occurred during initial graft rewarming (-192+/-176 pg/ml) and a positive difference of interleukin 8 occurred after hepatic artery declamping (17+/-23 pg/ml, both P<0.05). Conclusions. Hepatic sequestration and transhepatic activation of neutrophils, and hepatic production of interleukin 8 occur during clinical liver transplantation. A splanchnic influx of interleukin 6 occurs to the graft, possibly modulating neutrophil-mediated graft reperfusion injury.

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Documento generato il 06/04/20 alle ore 02:02:32