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Titolo:
Cyclosporine A and azathioprine are equipotent in chronic kidney allograftrejection
Autore:
Hamar, P; Liu, SY; Viklicky, O; Szabo, A; Muller, V; Heemann, U;
Indirizzi:
Univ Hosp Essen, Dept Nephrol, D-45122 Essen, Germany Univ Hosp Essen Essen Germany D-45122 pt Nephrol, D-45122 Essen, Germany Semmelweis Univ Med, Sch Med, Inst Pathophysiol, H-1089 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1089 ol, H-1089 Budapest, Hungary
Titolo Testata:
TRANSPLANTATION
fascicolo: 7, volume: 69, anno: 2000,
pagine: 1290 - 1295
SICI:
0041-1337(20000415)69:7<1290:CAAAAE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; RAT RENAL-ALLOGRAFTS; HUMAN T-CELLS; EXPRESSION; SURVIVAL; GLOMERULOSCLEROSIS; TRANSPLANTATION; PATHOGENESIS; LYMPHOCYTES; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Heemann, U Univ Essen Gesamthsch Klinikum, Nierentransplantat Ambulanz, Hufelandstr 55, D-45122 Essen, Germany Univ Essen Gesamthsch Klinikum Hufelandstr 55 Essen Germany D-45122
Citazione:
P. Hamar et al., "Cyclosporine A and azathioprine are equipotent in chronic kidney allograftrejection", TRANSPLANT, 69(7), 2000, pp. 1290-1295

Abstract

Chronic rejection is the major cause of graft loss after kidney transplantation. Various immunosuppressive protocols have been used to ameliorate this process. We investigated whether cyclosporin A- (CyA) or azathioprine- (Aza) based immunosuppression is better able to slow the progression of chronic rejection. Fisher kidneys were transplanted into bilaterally nephrectomized Lewis rats. Recipients received CyA (1.5 mg/kg/day, s.c.) for 10 days, and were treated from day II with either CyA (1.5 mg/kg)+pred (0.15 mg/kg) (C+P), Aza (2 mg/kg) +pred (A+P), vehicle+pred (P), or vehicle alone (controls) (n=8/group). Proteinuria was regularly assessed and grafts were harvested for morphological, immunohistological, and molecular biological analysis at week 24. By week 12 proteinuria had increased to significant levels. At week 24, proteinuria was significantly lower and creatinine clearance wassignificantly higher in CSP and A+P, than in P or controls. Morphological analysis supported these functional results: at week 24, glomerulopathy, tubular atrophy and intimal proliferation (as assessed according to the BANFFscore) were less pronounced in CSP and A+P, as compared with P or controls. These morphological parameters were accompanied by a reduced infiltrationof ED-1 + macrophages and CD-5 + T lymphocytes. In P or controls the synthesis of IL-2R alpha mRNB was markedly elevated at this time. In parallel tothe reduced cellular infiltration, IL-2R alpha mRNA expression was markedly inhibited, both, in C+P and A+P. There were no significant differences between CSP and A+P regarding the parameters studied. In conclusion, both C+Pand A+P reduced the infiltration of activated T lymphocytes, and the pace of chronic kidney allograft rejection. The outcome of C+P and A+P based therapy did not differ significantly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:31:25