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Titolo:
Familial vs sporadic rheumatoid arthritis (RA). A prospective study in an early RA inception cohort
Autore:
Radstake, TRDJ; Barrera, P; Albers, JMC; Swinkels, HL; van de Putte, LBA; van Riel, PLCM;
Indirizzi:
Univ Nijmegen Hosp, Dept Rheumatol, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp Nijmegen Netherlands NL-6500 HB Nijmegen, Netherlands
Titolo Testata:
RHEUMATOLOGY
fascicolo: 3, volume: 39, anno: 2000,
pagine: 267 - 273
SICI:
1462-0324(200003)39:3<267:FVSRA(>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE SEVERITY; PROGNOSTIC FACTORS; HLA-DRB1 GENES; SUSCEPTIBILITY; ASSOCIATION; NATIONWIDE; DAMAGE; HLA; CONCORDANCE; PROGRESSION;
Keywords:
rheumatoid arthritis; familial aggregation; early RA inception cohort;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Barrera, P Univ Nijmegen Hosp, Dept Rheumatol, POB 9101, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp POB 9101 Nijmegen Netherlands NL-6500 HB ds
Citazione:
T.R.D.J. Radstake et al., "Familial vs sporadic rheumatoid arthritis (RA). A prospective study in an early RA inception cohort", RHEUMATOLOG, 39(3), 2000, pp. 267-273

Abstract

Objectives. To study potential differences in demographic, process and outcome variables between familial and sporadic rheumatoid arthritis (RA) in an early RA inception cohort. Methods. In 1998, we ascertained the familial status of all collaborative patients in a large early RA inception cohort at our department. Familial RA was defined by the presence of at least two siblings fulfilling the American College of Rheumatology criteria for RA. Baseline demographic data and prospectively recorded disease activity variables, therapies and radiological damage during the first 6 yr of disease were included in the analysis. Aregression analysis was performed to assess whether familial clustering isa prognostic factor. Results. We identified 142 patients with sporadic and 36 with familial RA. The most striking difference between these groups was the larger sibship size in multicase families (8.2 +/- 2.5 vs 5.5 +/- 2.8; P < 0.0001). Age at onset was similar in both groups, although males with familiar RA were younger at disease onset than those with sporadic RA (median 50 vs 57 yr; P = 0.03). No differences were found in gender, presence of rheumatoid factor (RF), antinuclear factor and HLA-DR typing or in disease activity, interventions and outcome over 6 yr of follow-up. Early radiological damage and disease activity, but not familial history of RA were prognostic for X-ray damage. Conclusion. We show that sibship size is the only relevant risk factor forfamilial RA. No differences in genotypic and phenotypic characteristics, disease severity or radiological damage were observed among familial and sporadic RA. Familial history of RA is not a poor prognostic factor. This prospective study confirms previous cross-sectional findings in the Dutch population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 13:45:40