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Titolo:
Reperfused rat myocardium subjected to various durations of ischemia: Estimation of the distribution volume of contrast material with echo-planar a IR imaging
Autore:
Arheden, H; Saeed, M; Higgins, CB; Gao, DW; Ursell, PC; Bremerich, L; Wyttenbach, R; Dae, MW; Wendland, RF;
Indirizzi:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
RADIOLOGY
fascicolo: 2, volume: 215, anno: 2000,
pagine: 520 - 528
SICI:
0033-8419(200005)215:2<520:RRMSTV>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR COLLAGEN MATRIX; GD-DTPA; MICROVASCULAR INJURY; INFARCTED MYOCARDIUM; CANINE MYOCARDIUM; BLOOD-FLOW; ENHANCEMENT; IDENTIFICATION; TOMOGRAPHY; VIABILITY;
Keywords:
heart, experimental studies; heart, MR; myocardium, infarction; myocardium, ischemia; myocardium, radionuclide studies; radionuclide imaging, experimental studies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Higgins, CB Univ Calif San Francisco, Dept Radiol, 505 Parnassus Ave,L308,San Francisco, CA 94143 USA Univ Calif San Francisco 505 Parnassus Ave,L308 San Francisco CA USA 94143
Citazione:
H. Arheden et al., "Reperfused rat myocardium subjected to various durations of ischemia: Estimation of the distribution volume of contrast material with echo-planar a IR imaging", RADIOLOGY, 215(2), 2000, pp. 520-528

Abstract

PURPOSE: To estimate and compare the fractional distribution volume (fDV) of gadodiamide injection and technetium 99m-diethylenetriaminepentaacetic acid (DTPA) in the reperfused myocardium of rat hearts subjected to various durations of ischemia. MATERIALS AND METHODS: Magnetic resonance (MR) imaging and autoradiographywere performed in rats subjected to 20, 30, 40, or 60 minutes of regional ischemia followed by 1 hour of reperfusion. The fDVs of gadodiamide injection and Tc-99m-DTPA were measured and compared by using inversion-recovery echo-planar imaging and autoradiographic phosphor imaging, respectively. RESULTS: The mean fDV of both tracers (gadodiamide and Tc-99m-DTPA) in normal myocardium was 18% +/- 1, whereas that in the entire area at risk increased significantly (P < .05) with 20, 30, 40, and 60 minutes of ischemia to32% +/- 1, 57% +/- 4, 66% +/- 2, and 68% +/- 2, respectively. The fDV was significantly (P < .05) greater in the core of infarction-78% +/- 4, 89% +/- 5, and 88% +/- 5 with 30, 40, and 60 minutes of ischemia, respectively-than in the normal myocardium or in the area at risk. CONCLUSION: The fDV of MR contrast material in the periinfarcted rim was significantly (P < .05) greater than that in the normal myocardium, but significantly less than that in the core of infarcted myocardium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:02:57