Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Relating acoustic startle reactivity and plasticity to alcohol consumptionin male Wistar rats
Autore:
Sandbak, T; Rimol, LM; Jellestad, FK; Murison, R;
Indirizzi:
Univ Bergen, Dept Biol & Med Psychol, Div Physiol Psychol, N-5009 Bergen, Norway Univ Bergen Bergen Norway N-5009 Physiol Psychol, N-5009 Bergen, Norway
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 5, volume: 68, anno: 2000,
pagine: 723 - 733
SICI:
0031-9384(200003)68:5<723:RASRAP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; POSTTRAUMATIC-STRESS-DISORDER; MESOLIMBIC DOPAMINE SYSTEM; FEAR-POTENTIATED STARTLE; LONG-TERM HABITUATION; ROMAN HIGH-AVOIDANCE; AVOIDING ANA RATS; SCHIZOPHRENIC-PATIENTS; NUCLEUS-ACCUMBENS; ANIMAL-MODELS;
Keywords:
acoustic startle response; habituation; prepulse inhibition; ethanol consumption; ethanol withdrawal; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Sandbak, T Univ Bergen, Dept Biol & Med Psychol, Div Physiol Psychol, Aarstadveien 21, N-5009 Bergen, Norway Univ Bergen Aarstadveien 21 Bergen Norway N-5009 ergen, Norway
Citazione:
T. Sandbak et al., "Relating acoustic startle reactivity and plasticity to alcohol consumptionin male Wistar rats", PHYSL BEHAV, 68(5), 2000, pp. 723-733

Abstract

The purpose of this study was to investigate the relationship between the startle response and ethanol. Aspects of the startle response, including initial and average startle, habituation, and prepulse inhibition (PPI) were studied. The startle response was measured to detect potential predictors of voluntary ethanol consumption and to observe whether ethanol ingestion would affect startle in subsequent tests. Rats were tested three times in a standard startle chamber. After the initial startle test, rats categorized as showing high or low PPI were allocated in a balanced way to a free-choiceethanol-water regime or to the water-regime control group. At the end of the ethanol period (lasting for 16 days, including access to ethanol for 10 days), the rats were tested again in the startle chamber 24 h after ethanolremoval. After 5 weeks of ethanol abstinence, rats were exposed to a finalstartle test. The response to the first 120-dB stimulus showed an invertedU-shaped. curvilinear relationship to later ethanol consumption. Startle habituation appeared to have predictive value regarding ethanol consumption,with rats showing the most efficient habituation drinking most. Data showed no relationship between PPI and ethanol intake. Rats given access to ethanol showed greater habituation in the post-ethanol test than did the water controls. After 5 weeks of abstinence. low ethanol-consuming rats showed lower startle responses to the first 120-dB stimulus than did high ethanol-consuming rats. The present data suggest a two-way relationship between startle response characteristics and alcohol. (C) 2000 Elsevier Science Inc. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:35:21