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Titolo:
Serum intercellular adhesion molecule-1 levels and histologic chorioamnionitis
Autore:
Steinborn, A; Sohn, C; Scharf, A; Geka, F; Heger, S; Kaufmann, M;
Indirizzi:
Univ Frankfurt, Dept Obstet & Gynecol, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 col, D-60590 Frankfurt, Germany
Titolo Testata:
OBSTETRICS AND GYNECOLOGY
fascicolo: 5, volume: 95, anno: 2000,
pagine: 671 - 676
SICI:
0029-7844(200005)95:5<671:SIAMLA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMNIOTIC-FLUID INTERLEUKIN-6; TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; BLOOD-CELL COUNT; PRETERM LABOR; INTACT MEMBRANES; TERM; PARTURITION; INFECTION; CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Steinborn, A Univ Frankfurt, Dept Obstet & Gynecol, Theodor Stern Kai 7, D-60590 Frankfurt, Germany Univ Frankfurt Theodor Stern Kai 7 Frankfurt Germany D-60590
Citazione:
A. Steinborn et al., "Serum intercellular adhesion molecule-1 levels and histologic chorioamnionitis", OBSTET GYN, 95(5), 2000, pp. 671-676

Abstract

Objective: To compare the diagnostic value of intercellular adhesion molecule (ICAM)-1 with that of C-reactive protein (CRP) and white blood cell (WBC) count for detecting histologic chorioamnionitis in serum of women with preterm labor. Methods: Maternal blood was collected from 97 consecutive women admitted with preterm delivery before 37 weeks' gestation, and 50 women after normal term delivery (38-41 weeks' gestation). Intercellular adhesion molecule-1, CRP, and WBC count were measured before delivery. Results: Histologic chorioamnionitis was diagnosed in 48 of 97 women (48%)who delivered preterm and in none who delivered at term. Maternal serum levels of ICAM-1 (median 169 ng/mL, range 94-510 ng/mL, P <.001), CRP (median2.8 ng/mL, range 0.5-13.2 mg/dL, P <.001) and WBC count (12.6 x 10(3)/mu L, range 6.4-30.6 x 10(3)/mu L, P <.02) were statistically significantly higher in women with histologic chorioamnionitis than those without it (ICAM-1median 70 ng/mL, range 23-107 ng/mL; CRP median 0.7 mg/dL, range 0.5-6.7 mg/dL; WBC count median 10.9 x 10(3)/mu L, range 4.3-22.2 x 10(3)/mu L). Thesensitivity and specificity of maternal serum ICAM-1 (cutoff 106 ng/mL), CRP (cutoff 1.1 mg/dL), and WBC count (cutoff 1.8 x 10(3)/mu L) for diagnosing histologic chorioamnionitis were 98.0% and 93.8%, 75.5% and 71.4%, and 63.3% and 61.2%, respectively. Conclusion: In women with preterm labor, ICAM-1 is a more reliable indicator of histologic chorioamnionitis than CRP or WBC count. (Obstet Gynecol 2000;95:671-6. (C) 2000 by The American College of Obstetricians and Gynecologists.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 12:58:57