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Titolo:
Waist-to-hip ratio, weight gain, and dietary and serum selenium are associated with DNA content flow cytometry in Barrett's esophagus
Autore:
Moe, GL; Kristal, AR; Levine, DS; Vaughan, TL; Reid, BJ;
Indirizzi:
Seattle Pacific Univ, Dept Family & Consumer Sci, Seattle, WA 98119 USA Seattle Pacific Univ Seattle WA USA 98119 umer Sci, Seattle, WA 98119 USA Fred Hutchinson Canc Res Ctr, Canc Prevent Res Program, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA Univ Washington, Nutr Sci Program, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 r Sci Program, Seattle, WA 98195 USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA DeAstra Merck, Wayne, PA USA DeAstra Merck Wayne PA USADeAstra Merck, Wayne, PA USA Fred Hutchinson Canc Res Ctr, Program Epidemiol, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Canc Prevent Res Program, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA Univ Washington, Dept Med, Div Gastroenterol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Gastroenterol, Seattle, WA 98195 USA
Titolo Testata:
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
fascicolo: 1, volume: 36, anno: 2000,
pagine: 7 - 13
SICI:
0163-5581(2000)36:1<7:WRWGAD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC CARDIA; ADENOCARCINOMA; PLASMA; PROGRESSION; OBESITY; SUPPLEMENTATION; ABNORMALITIES; CAROTENOIDS; CHOLESTEROL; POPULATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Moe, GL Seattle Pacific Univ, Dept Family & Consumer Sci, 3307 3rd Ave W, Seattle,WA 98119 USA Seattle Pacific Univ 3307 3rd Ave W Seattle WA USA 98119 98119 USA
Citazione:
G.L. Moe et al., "Waist-to-hip ratio, weight gain, and dietary and serum selenium are associated with DNA content flow cytometry in Barrett's esophagus", NUTR CANCER, 36(1), 2000, pp. 7-13

Abstract

This cross-sectional study reports associations between anthropometric measures, serum antioxidant concentrations, and present diet with measures of elevated cell proliferation in 51 patients with Barrett's esophagus. Cell proliferation was assessed as fractions of cells in the S and G(2) phases, measured in biopsies of Barrett's tissue and analyzed by DNA content flow cytometry. Elevated proportions in the S and G(2) phases predict progression to adenocarcinoma. The percentage of cells in the S phase was positively associated with waist-to-hip ratio (r = 0.33, p < 0.05) and negatively associated with serum and dietary selenium (r = -0.34 and -0.32, respectively, p < 0.05). The percentage of cells in the G(2) phase was positively associated with weight change from age 25 (r = 0.39, p < 0.01) and negatively associated with dietary selenium (r = -0.31, p < 0.05). Selenium from breads and grains was negatively associated with the percentage of cells in the S phase (r = -0.41, p < 0.01) and the percentage of cells in the G(2) phase (r = -0.41, p < 0.01). These results suggest that increasing weight gain in adulthood, increasing waist-to-hip ratio, and decreasing dietary selenium intake and serum levels increase the risk of progression of Barrett's esophagus to adenocarcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 20:12:37