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Titolo:
Neuroanatomical abnormalities in behaviorally characterized App(V717F) transgenic mice
Autore:
Dodart, JC; Mathis, C; Saura, J; Bales, KR; Paul, SM; Ungerer, A;
Indirizzi:
Univ Strasbourg 1, CNRS, URA 1295, F-67000 Strasbourg, France Univ Strasbourg 1 Strasbourg France F-67000 , F-67000 Strasbourg, France Lilly Res Labs, Div Neurosci, Indianapolis, IN 46285 USA Lilly Res Labs Indianapolis IN USA 46285 osci, Indianapolis, IN 46285 USA
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 2, volume: 7, anno: 2000,
pagine: 71 - 85
SICI:
0969-9961(200004)7:2<71:NAIBCA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; OBJECT-RECOGNITION MEMORY; ALZHEIMERS-DISEASE; NEURITE OUTGROWTH; BETA-PROTEIN; NEUROFIBRILLARY TANGLES; NEUROTROPHIC ACTIVITY; HIPPOCAMPAL-NEURONS; NEUROTOXIC LESIONS; FORNIX TRANSECTION;
Keywords:
transgenic mice; amyloid precursor protein; APP; Alzheimer's disease; synaptophysin; synaptic density; hippocampus; immunohistochemistry; computer-assisted image analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Dodart, JC Univ Strasbourg 1, CNRS, URA 1295, 7 Rue Univ, F-67000 Strasbourg, France Univ Strasbourg 1 7 Rue Univ Strasbourg France F-67000 France
Citazione:
J.C. Dodart et al., "Neuroanatomical abnormalities in behaviorally characterized App(V717F) transgenic mice", NEUROBIOL D, 7(2), 2000, pp. 71-85

Abstract

Histological analyses were performed on the brains of App(V717F) transgenic (Tg) mice previously studied in a battery of behavioral tests. We describe here the regional and age-dependent deposition of amyloid in both heterozygous and homozygous Tg mice. We also report that Tg mice show significant and age-dependent changes in synaptic density measured by synaptophysin immunoreactivity. Surprisingly, a rather marked hippocampal atrophy is observed as early as 3 months of age in Tg mice (20-40%). Statistical analyses revealed that the deficits in object recognition memory are related to the number of amyloid deposits in specific brain regions, whereas deficits in spatial reference and working memory are related to the changes in synaptic density and hippocampal atrophy. Our study suggests that the behavioral deficits observed in Tg mice are only in part related to amyloid deposition, but are also related to neuroanatomical alterations secondary to overexpressionof the App(V717F) transgene and independent of amyloid deposition. (C) 2000 Academia Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:02:55