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Titolo:
Cortical dysgenesis: recent aspects regarding pathogenesis and pathophysiology
Autore:
Redecker, C; Hagemann, G; Gressens, P; Evrard, P; Witte, OW;
Indirizzi:
Univ Dusseldorf, Neurol Klin, D-40225 Dusseldorf, Germany Univ DusseldorfDusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Hop Robert Debre, Serv Neurol Pediat, F-75019 Paris, France Hop Robert Debre Paris France F-75019 urol Pediat, F-75019 Paris, France
Titolo Testata:
NERVENARZT
fascicolo: 4, volume: 71, anno: 2000,
pagine: 238 - 248
SICI:
0028-2804(200004)71:4<238:CDRARP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
GER
Soggetto:
NEURONAL MIGRATION DISORDERS; PRENATAL METHYLAZOXYMETHANOL TREATMENT; SUBCORTICAL LAMINAR HETEROTOPIA; INTRACTABLE PARTIAL EPILEPSY; DEVELOPING CEREBRAL-CORTEX; DEVELOPING RAT-BRAIN; CAJAL-RETZIUS CELLS; IN-VITRO RECORDINGS; NEOCORTICAL STRUCTURES; PERIVENTRICULAR HETEROTOPIA;
Keywords:
brain development; cortical malformation; epilepsy; migration disorder; pathophysiology;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: Hagemann, G Univ Dusseldorf, Neurol Klin, Moorenstr 5, D-40225 Dusseldorf,Germany Univ Dusseldorf Moorenstr 5 Dusseldorf Germany D-40225 ermany
Citazione:
C. Redecker et al., "Cortical dysgenesis: recent aspects regarding pathogenesis and pathophysiology", NERVENARZT, 71(4), 2000, pp. 238-248

Abstract

Cortical dysgenesia are a heterogenous group of genetic or acquired disturbances of cortical development which, due to the enormous progress in modern neuroimaging techniques, are increasingly recognized in association with a variety of clinical disorders. The spectrum of clinical manifestations, depending on type and extent of the alterations, includes severe mental retardation and epilepsy as well as neuropsychological deficits and some psychiatric disorders. Although pathogenesis and pathophysiology of cortical dysgenesis are still not fully understood,the recent discovery of responsible genes, growth factors, neurotransmitters, and exogenous factors sheds light on elementary mechanisms. The development of animal models mimicking different types of human cortical malformations helped to increase further the understanding of functional consequences of focal cortical dysgenesis. Several studies on these models reveal widespread alterations of cortical connectivity and excitability which are probably of crucial importance in different clinical disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 04:54:13