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Titolo:
Cholesterol sulfate, an activator of protein kinase C mediating squamous cell differentiation: a review
Autore:
Kuroki, T; Ikuta, T; Kashiwagi, M; Kawabe, S; Ohba, M; Huh, N; Mizuno, K; Ohno, S; Yamada, E; Chida, K;
Indirizzi:
Showa Univ, Inst Mol Oncol, Shinagawa Ku, Tokyo 1428555, Japan Showa UnivTokyo Japan 1428555 Oncol, Shinagawa Ku, Tokyo 1428555, Japan Saitama Canc Ctr, Res Inst, Dept Biochem, Inamachi, Saitama 3620806, JapanSaitama Canc Ctr Inamachi Saitama Japan 3620806 i, Saitama 3620806, Japan Natl Childrens Med Res Ctr, Div Pediat Pharmacol, Setagaya Ku, Tokyo 1548509, Japan Natl Childrens Med Res Ctr Tokyo Japan 1548509 Ku, Tokyo 1548509, Japan Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan Showa Univ Tokyo Japan 1428555 obiol, Shinagawa Ku, Tokyo 1428555, Japan Toyama Med & Pharmaceut Univ, Fac Med, Dept Biochem, Sugitani, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Sugitani Toyama Japan 9300194 9300194, Japan Yokohama City Univ, Sch Med, Dept Biochem Med, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Univ Tokyo, Grad Sch Agr & Life Sci, Dept Anim Sci, Bunkyo Ku, Tokyo 1138657, Japan Univ Tokyo Tokyo Japan 1138657 Anim Sci, Bunkyo Ku, Tokyo 1138657, Japan
Titolo Testata:
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
fascicolo: 2-3, volume: 462, anno: 2000,
pagine: 189 - 195
SICI:
1383-5742(200004)462:2-3<189:CSAAOP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL HUMAN KERATINOCYTES; X-LINKED ICHTHYOSIS; ETA-ISOFORM; MOUSE SKIN; MIXED MICELLES; NPKC-ETA; EXPRESSION; DEFICIENCY; SULFOTRANSFERASE; CARCINOGENESIS;
Keywords:
protein kinase C; The eta isoform of protein kinase C; cholesterol sulfate; squamous cell differentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kuroki, T Showa Univ, Inst Mol Oncol, Shinagawa Ku, Tokyo 1428555, Japan Showa Univ Tokyo Japan 1428555 nagawa Ku, Tokyo 1428555, Japan
Citazione:
T. Kuroki et al., "Cholesterol sulfate, an activator of protein kinase C mediating squamous cell differentiation: a review", MUT RES-R M, 462(2-3), 2000, pp. 189-195

Abstract

Activity of protein kinase C (PKC) depends on the interaction with polar head-groups of two membrane lipids, i.e., phosphatidylserine and diacylglycerol, We demonstrated that cholesterol metabolism is directly involved in activation of the eta isoform of protein kinase C (PKC eta), which is predominantly expressed in epithelial tissues in close association with epithelialdifferentiation. We found that PKC eta was activated by cholesterol sulfate (CS), a metabolite of cholesterol formed during squamous cell differentiation. in the presence of CS, phorbol ester only weakly enhanced the activity of PKC eta. CS also activated PKC eta, PKC delta and PKC epsilon in a dose-dependent manner, when assayed using purified recombinant materials. However, when partially purified materials were used from overexpressing normalhuman keratinocytes, only PKC eta was activated by CS among the isoforms examined. All the existing lines of evidence, mainly supplied from our laboratory, suggest that CS is involved in a signal transduction of squamous cell differentiation and thereby modifying squamous cell carcinogenesis. (C) 2000 Elsevier Science B,V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:07:47