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Titolo:
Chronic repetitive transcranial magnetic stimulation enhances c-fos in theparietal cortex and hippocampus
Autore:
Hausmann, A; Weis, C; Marksteiner, J; Hinterhuber, H; Humpel, C;
Indirizzi:
Univ Innsbruck Hosp, Dept Psychiat, Lab Psychiat, A-6020 Innsbruck, Austria Univ Innsbruck Hosp Innsbruck Austria A-6020 , A-6020 Innsbruck, Austria
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 2, volume: 76, anno: 2000,
pagine: 355 - 362
SICI:
0169-328X(20000329)76:2<355:CRTMSE>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR MESSENGER-RNA; RAT-BRAIN; INDUCED SEIZURES; CELLULAR-LEVEL; PROTEIN; EXPRESSION; INCREASE; NEURONS; ISCHEMIA;
Keywords:
transcription factor; brain; depression; cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Humpel, C Univ Innsbruck Hosp, Dept Psychiat, Lab Psychiat, Anichstr 35, A-6020 Innsbruck, Austria Univ Innsbruck Hosp Anichstr 35 Innsbruck AustriaA-6020 ustria
Citazione:
A. Hausmann et al., "Chronic repetitive transcranial magnetic stimulation enhances c-fos in theparietal cortex and hippocampus", MOL BRAIN R, 76(2), 2000, pp. 355-362

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a novel non-invasive method with anti-depressant properties. However, the mechanism of activation on the cellular level is unknown. Twelve hours after the last chronic rTMS treatment (14 days, once per day, 20 Hz, 10 s, 75% machine output, the transcription factor c-fos was markedly increased in neurons in layers I-IVand VI of the parietal cortex and in few scattered neurons in the hippocampus of Sprague-Dawley rats. The cortical activation was not blocked by the NMDA antagonist MK-801. The increase of c-fos was not paralleled by an increased glial response and activation of cortical growth factors. Thus, it isconcluded that chronic rTMS differentially activates parietal cortical layers and this might be involved in mediating anti-depressant activity in other brain areas. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 08:45:13