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Titolo:
Effects of brain natriuretic peptide on pituitary-adrenal activation in rats
Autore:
Jaszberenyi, M; Bujdoso, E; Telegdy, G;
Indirizzi:
Albert Szent Gyorgyi Med Univ, Dept Pathophysiol, MTA, SZOTE,Neurohumoral Res Grp, H-6701 Szeged, Hungary Albert Szent Gyorgyi Med Univ Szeged Hungary H-6701 6701 Szeged, Hungary
Titolo Testata:
LIFE SCIENCES
fascicolo: 17, volume: 66, anno: 2000,
pagine: 1655 - 1661
SICI:
0024-3205(20000317)66:17<1655:EOBNPO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; PORCINE BRAIN; ATRIAL; SECRETION; LOCALIZATION; VASOPRESSIN; STRESS; SYSTEM; TISSUE; FAMILY;
Keywords:
brain natriuretic peptide; pituitary-adrenal system; ether stress; restraint stress; electric shock;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Telegdy, G Albert Szent Gyorgyi Med Univ, Dept Pathophysiol, MTA, SZOTE,Neurohumoral Res Grp, Semmelweis 1,POB 531, H-6701 Szeged, Hungary Albert Szent Gyorgyi Med Univ Semmelweis 1,POB 531 Szeged Hungary H-6701
Citazione:
M. Jaszberenyi et al., "Effects of brain natriuretic peptide on pituitary-adrenal activation in rats", LIFE SCI, 66(17), 2000, pp. 1655-1661

Abstract

The aim of this study was to characterize the effects of brain natriureticpeptide (BNP) on the hypothalamo-pituitary-adrenal (HPA) responses to different stress paradigms (ether stress, electric shock and restraint). Rats were subjected to the stressful stimuli after intracerebroventricular administration of BNP (32.5 ng - 6.5 mu g) and plasma corticosterone was used as an indicator of the HPA activation. BNP did not modify the basal secretion,but inhibited the stress-induced rise in plasma corticosterone in a dose-dependent manner. BNP proved most effective in decreasing the corticosteroneresponse to ether stress and attenuated the electric shock and restraint-induced HPA activation to a lesser extent. These results confirm the view that BNP takes part in the regulation of the HPA system.

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Documento generato il 28/09/20 alle ore 15:33:23