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Titolo:
OXYNTOMODULIN STIMULATES INTESTINAL GLUCOSE-UPTAKE IN RATS
Autore:
COLLIE NL; ZHU ZC; JORDAN S; REEVE JR;
Indirizzi:
TEXAS TECH UNIV,DEPT BIOL SCI,BOX 43131 LUBBOCK TX 79409 TEXAS TECH UNIV,INST BIOTECHNOL LUBBOCK TX 79409 UNIV CALIF LOS ANGELES,VET ADM WADSWORTH MED CTR,DEPT MED,SCH MED,DIGEST DIS RES CTR LOS ANGELES CA 90073
Titolo Testata:
Gastroenterology
fascicolo: 6, volume: 112, anno: 1997,
pagine: 1961 - 1970
SICI:
0016-5085(1997)112:6<1961:OSIGIR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NA+/GLUCOSE COTRANSPORTER SGLT1; SMALL-BOWEL; MESSENGER-RNA; BASOLATERAL MEMBRANES; PREPROGLUCAGON GENE; JEJUNAL ENTEROCYTES; SUGAR-TRANSPORT; ACID-SECRETION; LLC-PK1 CELLS; BRUSH-BORDER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
N.L. Collie et al., "OXYNTOMODULIN STIMULATES INTESTINAL GLUCOSE-UPTAKE IN RATS", Gastroenterology, 112(6), 1997, pp. 1961-1970

Abstract

Background & Aims: Enteroglucagon peptides have long been proposed asmediators of intestinal adaptation, including mucosal growth and nutrient absorptive capacity. The hypothesis that infusions of oxyntomodulin, a bioactive form of enteroglucagon, would stimulate glucose and amino acid uptake was tested and its effects were compared with those ofglucagon. Methods: Rats were infused intravenously via minipumps witheither saline, rat oxyntomodulin (0.47 nmol.kg(-1).h(-1)), or glucagon (0.88 nmol.kg(-1).h(-1)) for 7 days, and plasma hormone levels were measured. At death, intestinal dimensions and brush border uptake of D-glucose and L-proline were measured using an in vitro everted sleeve technique. Results: Plasma enteroglucagon and glucagon levels were increased 4-and 12-fold, respectively, but there were no effects on food intake, body weight, or intestinal dimensions. In contrast, oxyntomodulin and glucagon significantly stimulated total intestinal glucose uptake capacity by 44% and 53%, respectively, over controls. Oxyntomodulin most potently enhanced glucose uptake in the ileum (215%), whereas glucagon's greatest effect was in the jejunum (63%-85%). However, neither peptide affected proline uptake. Conclusions: These results supporta new, specific action for oxyntomodulin in intestinal adaptation as a glucose uptake stimulator and confirm glucagon's role as a regulatorof glucose uptake.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 06:05:29