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Titolo:
Isolation of Borna disease virus from human brain tissue
Autore:
Nakamura, Y; Takahashi, H; Shoya, Y; Nakaya, T; Watanabe, M; Tomonaga, K; Iwahashi, K; Ameno, K; Momiyama, N; Taniyama, H; Sata, T; Kurata, T; De la Torre, JC; Ikuta, K;
Indirizzi:
Scripps Clin & Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 col, La Jolla, CA 92037 USA Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628640, Japan Natl Inst Infect Dis Tokyo Japan 1628640 injuku Ku, Tokyo 1628640, Japan Rakuno Gakuen Univ, Sch Vet Med, Dept Pathol, Ebetsu, Hokkaido 0698501, Japan Rakuno Gakuen Univ Ebetsu Hokkaido Japan 0698501 Hokkaido 0698501, Japan Kagawa Med Coll, Dept Neuropsychiat, Kagawa 7610007, Japan Kagawa Med Coll Kagawa Japan 7610007 europsychiat, Kagawa 7610007, Japan Osaka Univ, Microbial Dis Res Inst, Dept Virol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 t Virol, Suita, Osaka 5650871, Japan Hokkaido Univ, Sect Serol, Inst Immunol Sci, Kita Ku, Sapporo, Hokkaido 0600815, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600815 oro, Hokkaido 0600815, Japan
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 10, volume: 74, anno: 2000,
pagine: 4601 - 4611
SICI:
0022-538X(200005)74:10<4601:IOBDVF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MERIONES-UNGUICULATUS; PSYCHIATRIC-PATIENTS; BIPOLAR DISORDER; INFECTION; RNA; SCHIZOPHRENIA; ANTIBODIES; CELLS; BDV; ENCEPHALITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: De la Torre, JC Scripps Clin & Res Inst, Dept Neuropharmacol, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA Scripps Clin & Res Inst 10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
Y. Nakamura et al., "Isolation of Borna disease virus from human brain tissue", J VIROLOGY, 74(10), 2000, pp. 4601-4611

Abstract

Serological and molecular epidemiological studies indicate that Borna disease virus (BDV) can infect humans and is possibly associated with certain neuropsychiatric disorders. We examined brain tissue collected at autopsy from four schizophrenic patients and two healthy controls for the presence ofBDV markers in 12 different brain regions. BDV RNA and antigen was detected in four brain regions of a BDV-seropositive schizophrenic patient (P2) with a very recent (2 years) onset of disease. BDV markers exhibited a regionally localized distribution. BDV RNA was found in newborn Mongolian gerbilsintracranially inoculated with homogenates from BDV-positive brain regionsof P2. Human oligodendroglia (OL) cells inoculated with brain homogenates from BDV-positive gerbils allowed propagation and isolation of BDVHuP2br, ahuman brain-derived BDV Virus isolation was also possible by transfection of Vero cells with ribonucleoprotein complexes prepared from BDV-positive human and gerbil brain tissues. BDVHuP2br was genetically closely related tobut distinct from previously reported human- and animal-derived BDV sequences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:20:04