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Titolo:
Hypoxic-ischemic tolerance induced by hyperthermic pretreatment in newbornrats
Autore:
Ota, A; Ikeda, T; Xia, XY; Xia, YX; Ikenoue, T;
Indirizzi:
Miyazaki Med Coll, Dept Obstet & Gynecol, Miyazaki 88916, Japan Miyazaki Med Coll Miyazaki Japan 88916 & Gynecol, Miyazaki 88916, Japan
Titolo Testata:
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
fascicolo: 2, volume: 7, anno: 2000,
pagine: 102 - 105
SICI:
1071-5576(200003/04)7:2<102:HTIBHP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CEREBRAL-ISCHEMIA; BRAIN; PROTEINS; DAMAGE; INJURY;
Keywords:
hypoxic-ischemic tolerance; hyperthermia; heat-shock protein; brain damage; newborn rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Ikeda, T Miyazaki Med Coll, Dept Obstet & Gynecol, 5200 Kihara, Miyazaki 88916, Japan Miyazaki Med Coll 5200 Kihara Miyazaki Japan 88916 88916, Japan
Citazione:
A. Ota et al., "Hypoxic-ischemic tolerance induced by hyperthermic pretreatment in newbornrats", J SOC GYN I, 7(2), 2000, pp. 102-105

Abstract

OBJECTIVE: We investigated the effect of hyperthermic pretreatment 24 hours before hypoxic-ischemic on neuronal cell damage in 7-day-old mts. METHODS: Newborn rats were separated on postnatal day 7 into two groups 1)preheated (those exposed to 2 hours of hyperthermic pretreatment at 42-43C) (n = 29), and 2) nonheated (n = 20). At 24 hours after the Il)hyperthermic stress, rats from both groups were subjected to left carotid artery ligation followed by 2 hours of hypoxia (8% oxygen/92% nitrogen) at 33C. All rats were killed 1 week after hypoxia-ischemia, and brains were extracted for histologic study. A different group of 7-day-old vats (n = 8) was placed inthe same hyperthermic environment as mentioned above for 2 hours, and 24 hours after heat exposure brains were extracted for immunohistochemistry of heat-shock protein 70. RESULTS: The fetal incidence of hypoxic-ischemic brain damage significantly decreased in the preheated group (12 of 25 [48%] compared with the nonheated group (17 of 20 [85%]; P < .03). The induction of immunoreactive heat-shock protein 70 was observed mainly in glial and vascular endothelial cellsand, in a lesser amount, in neuronal cells of the cerebral cortex and hippocampus. CONCLUSION: Incidence of hypoxic-ischemia brain damage is consistently reduced by 2 hours of hyperthermic pretreatment in 7-day-old vats. Copyright (C) 2000 by the Society for Gynecologic Investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:06:39