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Titolo:
Evaluation of myocardial infarct size in rat heart by pinhole SPECT
Autore:
Hirai, T; Nohara, R; Hosokawa, R; Tanaka, M; Inada, H; Fujibayashi, Y; Fujita, M; Konishi, J; Sasayama, S;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068397, Japan Kyoto Univ Kyoto Japan 6068397 ovasc Med, Sakyo Ku, Kyoto 6068397, Japan Kyoto Univ, Grad Sch Med, Dept Pharmacol, Kyoto 6068397, Japan Kyoto UnivKyoto Japan 6068397 Med, Dept Pharmacol, Kyoto 6068397, Japan Kyoto Univ, Grad Sch Med, Dept Nucl Med, Kyoto 6068397, Japan Kyoto Univ Kyoto Japan 6068397 Med, Dept Nucl Med, Kyoto 6068397, Japan
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 2, volume: 7, anno: 2000,
pagine: 107 - 111
SICI:
1071-3581(200003/04)7:2<107:EOMISI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRACER AUTORADIOGRAPHY; TOMOGRAPHY;
Keywords:
pinhole SPECT; myocardial infarction; myocardial perfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Nohara, R Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068397, Japan Kyoto Univ Kyoto Japan 6068397 Sakyo Ku, Kyoto 6068397, Japan
Citazione:
T. Hirai et al., "Evaluation of myocardial infarct size in rat heart by pinhole SPECT", J NUCL CARD, 7(2), 2000, pp. 107-111

Abstract

Background. High-resolution single photon emission computed tomography (SPECT) with a pinhole collimator is a new method for evaluating the regional properties of radiopharmaceuticals in small laboratory animals in vivo. Although several reports of normal images of rat taken by this new technique are available, there are as yet few reports on its use in disease models, such as myocardial infarction, In this study, we clearly visualized myocardial flow in the rat heart with myocardial infarction using this system, and evaluated the relationship between SPECT images and histologic analysis. Methods and Results, For visualization of myocardial flow in rat heart, Tl-201 images were taken just before and 24 days after left coronary artery ligation, The images were taken using a 4-head SPECT scanner with pinhole collimators. The percent infarct size on Tl-201-SPECT imaging (%SI) and the defect score were then assessed and compared with the percent infarct size on histologic analysis (%HI). Both the %SI and defect score correlated well with %HI (r = 0.97 and 0.74, respectively). Conclusion. Serial SPECT imaging using pinhole collimators permits estimates of myocardial flow even in small laboratory animals noninvasively in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 09:39:22