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Titolo:
Effect of L-arginine administration on myocardial thallium-201 perfusion during exercise in patients with angina pectoris and normal coronary angiograms
Autore:
Fujita, H; Yamabe, H; Yokoyama, M;
Indirizzi:
Kobe Univ, Sch Med, Dept Internal Med 1, Kobe, Hyogo 650, Japan Kobe UnivKobe Hyogo Japan 650 ept Internal Med 1, Kobe, Hyogo 650, Japan
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 2, volume: 7, anno: 2000,
pagine: 97 - 102
SICI:
1071-3581(200003/04)7:2<97:EOLAOM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; DEPENDENT VASODILATION; RISK-FACTORS; ATHEROSCLEROSIS; ACETYLCHOLINE; INFUSION; ISCHEMIA; INSULIN; HUMANS;
Keywords:
microvascular angina; exercise; thallium-201 scintigraphy; nitric oxide; L-arginine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Fujita, H Miki City Hosp, 58-1 Kasa, Miki, Hyogo 6730402, Japan Miki City Hosp 58-1 Kasa Miki Hyogo Japan 6730402 6730402, Japan
Citazione:
H. Fujita et al., "Effect of L-arginine administration on myocardial thallium-201 perfusion during exercise in patients with angina pectoris and normal coronary angiograms", J NUCL CARD, 7(2), 2000, pp. 97-102

Abstract

Objectives. We tested the hypothesis that an exogenous supplement of L-arginine could alleviate coronary perfusion abnormality during exercise in patients with angina pectoris and normal coronary arteries. Methods and Results. Twelve patients underwent exercise thallium-201 scintigraphy without medication (control) and after intravenous administration of L-arginine. Exercise time was prolonged in the L-arginine study compared with the control (482 s vs 540 s, P < .05), Tl-201 extent score was improved in the L-arginine study (0.33 vs 0.26, P < .05), and the severity score was also improved (23.7 vs 16.9, P < .05), In 7 of the 12 patients whose Tl-201 redistribution disappeared in the L-arginine study, the percent increase in serum L-citrulline concentration during exercise was larger than that of the remaining 5 patients (18% vs 0.9 %, P < .01). The percent reduction in epicardial coronary diameter in response to acetylcholine was also greater in the former group (28.3% vs 11,1%, P < .05). Conclusion. Exogenous L-arginine improved myocardial perfusion during exercise in a subset of patients with angina pectoris and normal coronary arteries, probably by increasing production of nitric oxide.

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Documento generato il 02/04/20 alle ore 19:04:38