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Titolo:
Identified motor terminals in Drosophila larvae show distinct differences in morphology and physiology
Autore:
Lnenicka, GA; Keshishian, H;
Indirizzi:
SUNY Albany, Dept Biol Sci, Albany, NY 12222 USA SUNY Albany Albany NY USA 12222 bany, Dept Biol Sci, Albany, NY 12222 USA Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06511 USA Yale Univ New Haven CT USA 06511 ular & Dev Biol, New Haven, CT 06511 USA
Titolo Testata:
JOURNAL OF NEUROBIOLOGY
fascicolo: 2, volume: 43, anno: 2000,
pagine: 186 - 197
SICI:
0022-3034(200005)43:2<186:IMTIDL>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTIC PLASTICITY; NEUROMUSCULAR-JUNCTIONS; FUNCTIONAL COMPONENTS; GRASSHOPPER EMBRYOS; TRANSMITTER RELEASE; GENETIC DISSECTION; GROWTH; MUSCLE; SYNAPSES; CRAYFISH;
Keywords:
Drosophila; synapse; motor terminal; Lucifer yellow; EPSP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Lnenicka, GA SUNY Albany, Dept Biol Sci, Albany, NY 12222 USA SUNY AlbanyAlbany NY USA 12222 ol Sci, Albany, NY 12222 USA
Citazione:
G.A. Lnenicka e H. Keshishian, "Identified motor terminals in Drosophila larvae show distinct differences in morphology and physiology", J NEUROBIOL, 43(2), 2000, pp. 186-197

Abstract

In Drosophila, the type I motor terminals innervating the larval ventral longitudinal muscle fibers 6 and 7 have been the most popular preparation for combining synaptic studies with genetics. We have further characterized the normal morphological and physiological properties of these motor terminals and the influence of muscle size on terminal morphology, Using dye-injection and physiological techniques, we show that the two axons supplying these terminals have different innervation patterns: axon 1 innervates only muscle fibers 6 and 7, whereas axon 2 innervates all of the ventral longitudinal muscle fibers. This difference in innervation pattern allows the two axons to be reliably identified. The terminals formed by axons 1 and 2 on muscle fibers 6 and 7 have the same number of branches; however, axon 2 terminals are approximately 30% Longer than axon 1 terminals, resulting in a corresponding greater number of boutons for axon 2. The axon 1 boutons are approximately 30% wider than the axon 2 boutons, The excitatory postsynaptic potential (EPSP) produced by axon 1 is generally smaller than that produced by axon 2, although the size distributions show considerable overlap. Consistent with vertebrate studies, there is a correlation between muscle fiber size and terminal size. For a single axon, terminal area and length, the number of terminal branches, and the number of boutons are all correlated withmuscle fiber size, but bouton size is not. During prolonged repetitive stimulation, axon 2 motor terminals show synaptic depression, whereas axon 1 EPSPs facilitate. The response to repetitive stimulation appears to be similar at all motor terminals of an axon, (C) 2000 John Wiley & Sons. Inc. J Neurobiol 43: 186-197. 2000.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 05:23:40