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Titolo:
Synthesis, spectroscopy, and cytotoxicity of glycosylated acetogenin derivatives as promising molecules for cancer therapy
Autore:
Queiroz, EF; Roblot, F; Duret, P; Figadere, B; Gouyette, A; Laprevote, O; Serani, L; Hocquemiller, R;
Indirizzi:
Univ Paris 11, Fac Pharm, Lab Pharmacognosie, UPRESA CNRS BioCIS 8076, F-92296 Chatenay Malabry, France Univ Paris 11 Chatenay Malabry France F-92296 6 Chatenay Malabry, France Univ Paris 11, Fac Pharm, Lab Cancerol, F-92296 Chatenay Malabry, France Univ Paris 11 Chatenay Malabry France F-92296 6 Chatenay Malabry, France CNRS, Inst Chim Subst Nat, Lab Spectrometrie Masse, F-91198 Gif Sur Yvette, France CNRS Gif Sur Yvette France F-91198 Masse, F-91198 Gif Sur Yvette, France
Titolo Testata:
JOURNAL OF MEDICINAL CHEMISTRY
fascicolo: 8, volume: 43, anno: 2000,
pagine: 1604 - 1610
SICI:
0022-2623(20000420)43:8<1604:SSACOG>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIS-TETRAHYDROFURAN ACETOGENIN; ENZYME PRODRUG THERAPY; ANNONACEOUS ACETOGENINS; RECENT PROGRESS; SEEDS; SPINESCENS; SQUAMOCIN; ROOTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Figadere, B Univ Paris 11, Fac Pharm, Lab Pharmacognosie, UPRESA CNRS BioCIS 8076, RueJean Baptiste Clement, F-92296 Chatenay Malabry, France Univ Paris 11 Rue Jean Baptiste Clement Chatenay Malabry France F-92296
Citazione:
E.F. Queiroz et al., "Synthesis, spectroscopy, and cytotoxicity of glycosylated acetogenin derivatives as promising molecules for cancer therapy", J MED CHEM, 43(8), 2000, pp. 1604-1610

Abstract

Several glycosyl derivatives of squamocin (1) have been synthesized by glycosylation under Lewis acid catalysis with two different 1-O-acetyl sugars. Separation of these compounds has been achieved by HPLC and centrifugal partition chromatography (CPC). A detailed NMR, ESIMS, and LSIMS study allowed complete structural elucidations. The cytotoxic activity of the glycosyl derivatives was investigated and compared with that of squamocin and drosquamocin against human epidermoid carcinoma cells (KB), African green monkey (Cercopithecus aethiops) kidney epithelial cells (VERO), and mouse lymphocytic leukemia cells (L1210). The antiproliferative effects of some derivatives were studied on cell cycles in mouse lymphocytic leukemia cells (L1210).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:34:43