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Titolo:
Humoral immune responses in Cr2(-/-) mice: Enhanced affinity maturation but impaired antibody persistence
Autore:
Chen, ZB; Koralov, SB; Gendelman, M; Carroll, MC; Kelsoe, G;
Indirizzi:
Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Med Ctr, Dept Immunol, Durham, NC 27710 USA Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Ctr Blood Res, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 9, volume: 164, anno: 2000,
pagine: 4522 - 4532
SICI:
0022-1767(20000501)164:9<4522:HIRICM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTER B-CELLS; FOLLICULAR DENDRITIC CELLS; COMPLEMENT RECEPTOR TYPE-2; T-DEPENDENT ANTIGEN; GERMINAL-CENTERS; IN-SITU; LYMPHOCYTES-B; GUINEA-PIGS; ACQUIRED-IMMUNITY; MOUSE COMPLEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Kelsoe, G Duke Univ, Med Ctr, Dept Immunol, Box 3010, Durham, NC 27710 USADuke Univ Box 3010 Durham NC USA 27710 010, Durham, NC 27710 USA
Citazione:
Z.B. Chen et al., "Humoral immune responses in Cr2(-/-) mice: Enhanced affinity maturation but impaired antibody persistence", J IMMUNOL, 164(9), 2000, pp. 4522-4532

Abstract

Deficiency in CD21/CD35 by disruption of the Cr2 loci leads to impaired humoral immune responses. In this study, we detail the role of CD21/CD35 on Ab responses to the hapten (4-hydroxy-3-nitrophenyl)acetyl conjugated to chicken gamma-globulin. Surprisingly, Cr2(-/-) mice generate significant Ab responses and germinal center (GC) reactions to low doses of this Ag in alum,although the magnitude of their responses is much reduced in comparison with those of Cr2(+/-) and C57BL/6 controls. Increasing Ag dose partially corrected this deficit. In situ study of the somatic genetics of GC B cells demonstrated that VDJ hypermutation does not require CD21/CD35, and Cr2(-/-) mice exhibited enhanced affinity maturation of serum Ab in the post-GC phase of the primary response. On the other hand, Cr2(-/-) mice displayed accelerated loss of serum Ab and long-lived Ab-forming cells. These observationssuggest that B-cell activation/survival signals mediated by CD21 and/or the retention of Ag by CD21/CD35 play important roles in the generation, quality, and maintenance of serum Ab. The Journal of Immunology, 2000, 164: 4522-4532.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:20:00