Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Drug interactions in palliative care
Autore:
Bernard, SA; Bruera, E;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Symptom Control & Palliat Care, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 rol & Palliat Care, Houston, TX 77030 USA Univ N Carolina, Div Hematol Med Oncol, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA ematol Med Oncol, Chapel Hill, NC USA
Titolo Testata:
JOURNAL OF CLINICAL ONCOLOGY
fascicolo: 8, volume: 18, anno: 2000,
pagine: 1780 - 1799
SICI:
0732-183X(200004)18:8<1780:DIIPC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; HUMAN-LIVER-MICROSOMES; SPARTEINE DEBRISOQUINE MONOOXYGENASE; HYDROXYLATION PHENOTYPE; O-DEMETHYLATION; PLASMA-LEVELS; PHARMACOKINETIC CONSIDERATIONS; TRICYCLIC ANTIDEPRESSANTS; CLINICAL PHARMACOKINETICS; HALOPERIDOL DISPOSITION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
148
Recensione:
Indirizzi per estratti:
Indirizzo: Bruera, E Univ Texas, MD Anderson Canc Ctr, Dept Symptom Control & PalliatCare, 1515 Holcombe Blvd,P12-2911, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd,P12-2911 Houston TX USA 77030 USA
Citazione:
S.A. Bernard e E. Bruera, "Drug interactions in palliative care", J CL ONCOL, 18(8), 2000, pp. 1780-1799

Abstract

Purpose: This review of drug interactions in palliative care examines the relevant literature in this area and summarizes the information on interactions of drugs, nutrients, and natural products that are used in the palliative care setting. particular emphasis is placed on describing the newer information on the cytochrome P450 (CYP) system and the interactions of opioids, anti-depressants, and the antitussive, dextromethorphan. Methods: We performed a search of the MEDLINE database of the rime period from 1966 until April 1998, using medical subject headings such as the names of selective serotonin reuptake inhibitors and other relevant medicationsin palliative care. Literature reviewed included both human and animal articles as well as non-English literature,Bibliographies of these articles and the personal libraries of several palliative care specialists were reviewed. Software developed by The Medical Letter-The Drug Interaction program was also used. Results: Drug interactions can be categorized in several ways. Drug-drug interactions are the most well known and can be kinetic, dynamic, or pharmaceutical. Pharmacokinetic interactions can involve CYP 2D6, which acts on drugs such as codeine and is responsible far its conversion to morphine. Poormetabolizers, either genotypic or due to phenocopying, are at risk for undertreatment if not recognized. Pharmacodynamic interactions with dextromethorphan may produce serotonin syndrome. Conclusion: Drug interactions are important in palliative care as in otheraspects of medicine. these interactions are similar to those seen in otherareas of medical care but have significant consequences in pain management. Failure to recognize these interactions can lead to either overdosing or undertreatment. J Clin Oncol 18:1786-1799. (C) 2000 by American Society of Clinical Oncology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:28:09