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Titolo:
Immune mechanisms of smooth muscle hyperreactivity in asthma
Autore:
Schmidt, D; Rabe, KF;
Indirizzi:
Leiden Univ, Med Ctr, Dept Pulmonol, NL-2300 RC Leiden, Netherlands LeidenUniv Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands
Titolo Testata:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
fascicolo: 4, volume: 105, anno: 2000,
pagine: 673 - 682
SICI:
0091-6749(200004)105:4<673:IMOSMH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; BRONCHIAL BIOPSY SPECIMENS; SERUM IGE LEVELS; AIRWAY HYPERRESPONSIVENESS; PASSIVE SENSITIZATION; T-LYMPHOCYTES; IMMUNOGLOBULIN-E; ALTERED RESPONSIVENESS; CONTRACTILE RESPONSES; CIGARETTE SMOKERS;
Keywords:
immune mechanisms; bronchial smooth muscle; hyperreactivity; asthma; sensitization; IgE; cytokines; airway inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Rabe, KF Leiden Univ, Med Ctr, Dept Pulmonol, C3-P,POB 9600, NL-2300 RC Leiden, Netherlands Leiden Univ C3-P,POB 9600 Leiden Netherlands NL-2300 RC herlands
Citazione:
D. Schmidt e K.F. Rabe, "Immune mechanisms of smooth muscle hyperreactivity in asthma", J ALLERG CL, 105(4), 2000, pp. 673-682

Abstract

Asthma is characterized by bronchial hyperresponsiveness to a variety of bronchospasmogenic stimuli. To study the pathophysiologic mechanisms underlying the increased sensitivity and degree of maximal airway narrowing, various in vivo and in vitro models have been developed with methods of active and passive sensitization. These studies indicated a major role for alterations in the smooth muscle itself rather than neural dysfunction or airway inflammation as the underlying cause for the development of bronchial hyperresponsiveness. During the last years smooth muscle cells were found to exhibit not only the "classical" contractile phenotype hut also a proliferative-synthetic phenotype, which is capable of producing proinflammatory cytokines, chemotaxins, and growth factors. Allergic sensitization can alter both contractile and secretory functions, thereby indicating that the smooth muscle cell could contribute directly to the persistence of airway inflammationin asthma, ri better understanding of the changes within the smooth musclecells and of the mechanisms that lead to their induction could contribute to the development of novel therapeutic approaches for the treatment of asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:13:06