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Titolo:
Redistribution of selectin counter-ligands induced by cytokines
Autore:
Nagata, K; Tsuji, T; Matsushima, K; Hanai, N; Irimura, T;
Indirizzi:
Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Canc Biol & Mol Immunol, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Immunol, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo, Sch Med, Dept Mol Prevent Med, Bunkyo Ku, Tokyo 1130033, JapanUniv Tokyo Tokyo Japan 1130033 vent Med, Bunkyo Ku, Tokyo 1130033, Japan Kyowa Hakko Kogyo Co Ltd, Tokyo Res Labs, Tokyo 1940023, Japan Kyowa HakkoKogyo Co Ltd Tokyo Japan 1940023 Labs, Tokyo 1940023, Japan
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 4, volume: 12, anno: 2000,
pagine: 487 - 492
SICI:
0953-8178(200004)12:4<487:ROSCIB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIALYL-LEWIS-X; P-SELECTIN; ACTIVATED PLATELETS; REPERFUSION INJURY; HUMAN NEUTROPHILS; ADHESION; SUPEROXIDE; INTERLEUKIN-8; INFLAMMATION; ENDOTHELIUM;
Keywords:
neutrophils; selectin ligand; sialyl Lewis X; superoxide anion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Irimura, T Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Canc Biol & Mol Immunol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1130033 okyo 1130033, Japan
Citazione:
K. Nagata et al., "Redistribution of selectin counter-ligands induced by cytokines", INT IMMUNOL, 12(4), 2000, pp. 487-492

Abstract

Soluble recombinant (r) P-selectin and rP-selectin immobilized on plastic surfaces were tested for their capacity to activate neutrophils to produce superoxide anion. Soluble rP-selectin was incapable of activating leukocytes, whereas immobilized rP-selectin was able to induce leukocyte activation. When neutrophils were pretreated with a low dose of IL-8, granulocyte colony stimulating factor or granulocyte macrophage colony stimulating factor, soluble rP-selectin was no longer inert. These cytokine-primed leukocytes produced superoxide anion in the presence of soluble rP-selectin, During this priming period, sialyl Lewis X (sLe(x)) epitopes redistributed to one endof the leukocytes. Similar polarization of sLe(x) epitopes was observed atthe attachment site of cells that adhered to immobilized rP-selectin. Cap formation and superoxide anion production induced by solid-phase P-selectinor by IL-8 and soluble rP-selectin treatment were inhibited by treatment of the leukocytes with cytochalasin B. These observations suggest that the redistribution of the carbohydrate ligands and the polarization of the leukocyte surface through an active process is a prerequisite but not sufficientto leukocyte superoxide production through P-selectin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:27:56