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Titolo:
5-HT1A and beyond: The role of serotonin and its receptors in depression and the antidepressant response
Autore:
Cryan, JF; Leonard, BE;
Indirizzi:
Natl Univ Ireland Univ Coll Galway, Dept Pharmacol, Galway, Ireland Natl Univ Ireland Univ Coll Galway Galway Ireland acol, Galway, Ireland
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 2, volume: 15, anno: 2000,
pagine: 113 - 135
SICI:
0885-6222(200003)15:2<113:5ABTRO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; IMIPRAMINE BINDING-SITES; PLACEBO-CONTROLLED TRIAL; IN-VIVO MICRODIALYSIS; RAT DORSAL RAPHE; MAJOR DEPRESSION; SUICIDE VICTIMS; FRONTAL-CORTEX; GUINEA-PIG; RELEASE INVIVO;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
247
Recensione:
Indirizzi per estratti:
Indirizzo: Cryan, JF Univ Penn, Dept Pharmacol, 320 John Morgan Bldg,Mailcode 6084,3620 Hamilton, Philadelphia, PA 19104 USA Univ Penn 320 John Morgan Bldg,Mailcode 6084,3620 Hamilton Philadelphia PA USA 19104
Citazione:
J.F. Cryan e B.E. Leonard, "5-HT1A and beyond: The role of serotonin and its receptors in depression and the antidepressant response", HUM PSYCHOP, 15(2), 2000, pp. 113-135

Abstract

Since its discovery 50 years ago, the role of the indoleamine 5-HT (5-hydroxytryptamine; serotonin) in the pathogenesis of depression and in the mechanism of action of antidepressant drugs has been the subject of considerable research. Advances in molecular biology and radioligand techniques have led to the functional characterisation of at least 14 serotonin receptor subtypes. This classification has led to the development of selective compounds that have aided in the efforts of dissecting the complex role of 5-HT in depression and in mediating the antidepressant response. This review focuses largely on novel strategies of targeting specific 5-HT receptors subtypes, especially the presynaptic 5-HT1A and 5-HT1B/1D receptors. These subtypesare of primary importance in that they control the firing of the 5-HT neuron and the release of 5-HT. In addition, a number of postsynaptic 5-HT receptors have been shown to be dysfunctional in depression and are also potential targets for a number of antidepressants. We conclude that selective targeting of 5-HT receptors may lead to a faster acting and more efficient antidepressant response. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:32:59