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Titolo:
Comparison of the effect of levodopa and bromocriptine on naloxone-precipitated morphine withdrawal symptoms in mice
Autore:
Samini, M; Fakhrian, R; Mohagheghi, M; Dehpour, AR;
Indirizzi:
Tehran Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran Tehran Univ MedSci Tehran Iran , Sch Med, Dept Pharmacol, Tehran, Iran
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 2, volume: 15, anno: 2000,
pagine: 95 - 101
SICI:
0885-6222(200003)15:2<95:COTEOL>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINERGIC-NEURONS; BETA-ENDORPHIN; RATS; RECEPTORS; RELEASE; BRAIN; DRUGS; APOMORPHINE; INVOLVEMENT; DEPENDENCE;
Keywords:
levodopa; bromocriptine; morphine withdrawal symptoms; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Dehpour, AR Tehran Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran Tehran Univ Med Sci Tehran Iran ept Pharmacol, Tehran, Iran
Citazione:
M. Samini et al., "Comparison of the effect of levodopa and bromocriptine on naloxone-precipitated morphine withdrawal symptoms in mice", HUM PSYCHOP, 15(2), 2000, pp. 95-101

Abstract

In this study, the effect of 1-dopa and bromocriptine on morphine withdrawal syndrome was compared. Both 1-dopa (125, 250 mg/kg, i.p.) and low doses of bromocriptine (0.04, 0.08 mg/kg, i.p.) potentiated naloxone-induced morphine withdrawal symptoms such as jumping, climbing and rearing in mice. Higher doses of bromocriptine (0.16, 0.32 mg/kg, i.p.) attenuated these naloxone-induced symptoms. SKF 83566, D-1, dopamine antagonist (0.4, 0.8 mg/kg, i.p.) and sulpiride, D-1 dopamine antagonist (5, 10 mg/kg, i.p.) when used alone, also produced inhibitory effects on naloxone-induced morphine withdrawal symptoms. Pretreatment with sulpiride (5, 10 mg/kg, i.p.) and SKF 83566(0.4, 0.8 mg/kg, i.p.) attenuated the potentiating effects of 1-dopa on withdrawal symptoms significantly. Pretreatment with sulpiride also decreasedthe potentiating effect of bromocriptine and reinforced the inhibitory action of it, but SKF 83566 pretreatment just reinforced the effect of higher doses of bromocriptine. Concurrent pretreatment of animals with sulpiride (10 mg/kg, i.p.) and SKF 83566 (0.8 mg/kg, i.p.) markedly decreased the potentiating effects of 1-dopa and bromocriptine and reinforced the inhibitory action of bromocriptine on the naloxone-induced morphine withdrawal syndrome. Prazosin, alpha(1) antagonist (1, 2 mg/kg, i.p.) decreased the naloxone-induced morphine withdrawal syndrome significantly. Pretreatment with yohimbine, alpha(2)-antagonist (5 mg/kg, i.p.) reversed the inhibitory effects of bromocriptine (0.16, 0.32 mg/kg, i.p.) on naloxone-induced morphine withdrawal syndrome significantly. In conclusion, our results show that bromocriptine at lower doses (0.04, 0.08 mg/kg, i.p.) acts similar to 1-dopa, but at higher doses (0.16, 0.32 mg/kg, i.p.) shows different effects on naloxone-induced morphine withdrawal syndrome which may be due to the interaction of bromocriptine with alpha-adrenoceptors. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:06:00