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Titolo:
beta-globin gene haplotypes and alpha-thalassemia analysis in Babinga pygmies from Congo-Brazzaville
Autore:
Mouele, R; Bodo, JM; Mpele, DMB; Feingold, J; Galacteros, F;
Indirizzi:
Hop Henri Mondor, INSERM, Unite Rech Genet Mol & Hematol, U474, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 l, U474, F-94010 Creteil, France Minist Rech Sci & Tech, OCEAC, Yaounde, Cameroon Minist Rech Sci & Tech Yaounde Cameroon Tech, OCEAC, Yaounde, Cameroon Ctr Natl Transfus Sanguine, Brazzaville, Congo Ctr Natl Transfus SanguineBrazzaville Congo nguine, Brazzaville, Congo Univ Paris 07, INSERM, Lab Anthropol Biol, Unite Rech Genet Epidemiol,U155, Paris, France Univ Paris 07 Paris France ite Rech Genet Epidemiol,U155, Paris, France
Titolo Testata:
HUMAN BIOLOGY
fascicolo: 2, volume: 72, anno: 2000,
pagine: 379 - 383
SICI:
0018-7143(200004)72:2<379:BGHAAA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPLIFICATION; POLYMERASE; MALARIA;
Keywords:
Congo-Brazzaville; Babinga pygmies; epidemiology; beta-globin gene haplotypes; alpha(+)-thalassemia; anthropology; evolution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Mouele, R Hop Henri Mondor, INSERM, Unite Rech Genet Mol & Hematol, U474, 54 Ave Marechal Lattre de Tassigny, F-94010 Creteil, France Hop Henri Mondor 54 Ave Marechal Lattre de Tassigny Creteil France F-94010
Citazione:
R. Mouele et al., "beta-globin gene haplotypes and alpha-thalassemia analysis in Babinga pygmies from Congo-Brazzaville", HUMAN BIOL, 72(2), 2000, pp. 379-383

Abstract

We analyzed beta-globin gene cluster haplotypes and deletional alpha(+)-thalassemia (-alpha(3.7kb)) in 54 Babinga pygmy subjects from Congo-Brazzaville. The beta(S)-globin gene frequency was 0.065 and that of the deletional alpha-globin gene (-alpha(3.7kb)) was 0.29. Eighty-five percent of the beta(S) chromosomes and 13% of the beta(A) chromosomes were associated with theBantu haplotype, 10% of beta(A) chromosomes with the Senegal haplotype, and the remaining beta chromosomes with atypical haplotypes, None of the chromosomes were of the Benin haplotype, These results are clearly of anthropological and evolutionary interest. They also support earlier observations that alpha(+)-thalassemia is prevalent at a high frequency in African populations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:13:26