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Titolo:
Ventral subiculum administration of the somatostatin receptor agonist MK-678 increases dopamine levels in the nucleus accumbens
Autore:
Mitchell, SN; Sharrott, A; Cooper, J; Greenslade, RG;
Indirizzi:
Eli Lilly & Co, Lilly Res Ctr Ltd, Windlesham GU20 6PH, Surrey, England Eli Lilly & Co Windlesham Surrey England GU20 6PH 20 6PH, Surrey, England
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 395, anno: 2000,
pagine: 43 - 46
SICI:
0014-2999(20000421)395:1<43:VSAOTS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO; RAT; SCHIZOPHRENIA;
Keywords:
somatostatin; subiculum; somatostatin sst2 receptor; dopamine; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Mitchell, SN Eli Lilly & Co, Lilly Res Ctr Ltd, Erl Wood Manor, WindleshamGU20 6PH, Surrey, England Eli Lilly & Co Erl Wood Manor Windlesham Surrey England GU20 6PH
Citazione:
S.N. Mitchell et al., "Ventral subiculum administration of the somatostatin receptor agonist MK-678 increases dopamine levels in the nucleus accumbens", EUR J PHARM, 395(1), 2000, pp. 43-46

Abstract

Somatostatin (or somatotropin-release inhibitory factor, SRIF) binding andin situ hybridisation studies have indicated a high expression of receptorsubtypes throughout the rat brain and, in particular, in subregions of thehippocampus and subiculum. In vitro, somatostatin and related peptides, including seglitide (MK-678), hyperpolarise subicular neurones of the burst firing type-a response, which may have functional consequences for their output. One major projection from the subiculum is to the nucleus accumbens. The functional consequence of somatostatin receptor stimulation in the ventral subiculum has been assessed by measuring extracellular levels of dopamine in the ipsilateral nucleus accumbens. In anaesthetised rats, administration of seglitide (MK-678), a somatostatin analogue with selectivity for the SRIF-1 receptor (comprising somatostatin sst2, sst3 and sst5 subtypes) significantly increased extracellular levels of dopamine in the ipsilateral nucleus accumbens shell. The result suggests that hyperpolarisation of subicular neurones by MK-678 may lead to activation of the subiculo-accumbens projection system, and an associated increase in dopaminergic function. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 17:12:53